Reaction Details Report a problem with these data
Target
Serine/threonine-protein kinase 33
Ligand
BDBM50400683
Substrate
n/a
Meas. Tech.
ChEMBL_880288 (CHEMBL2216290)
IC50
580±n/a nM
Citation
 Weïwer, M; Spoonamore, J; Wei, J; Guichard, B; Ross, NT; Masson, K; Silkworth, W; Dandapani, S; Palmer, M; Scherer, CA; Stern, AM; Schreiber, SL; Munoz, B A Potent and Selective Quinoxalinone-Based STK33 Inhibitor Does Not Show Synthetic Lethality in KRAS-Dependent Cells. ACS Med Chem Lett 3:1034-1038 (2012) [PubMed]  Article 
Target
Name:
Serine/threonine-protein kinase 33
Synonyms:
STK33 | STK33_HUMAN | Serine/threonine-protein kinase 33
Type:
Enzyme Catalytic Domain
Mol. Mass.:
57833.21
Organism:
Homo sapiens (Human)
Description:
gi_23943882
Residue:
514
Sequence:
MADSGLDKKSTKCPDCSSASQKDVLCVCSSKTRVPPVLVVEMSQTSSIGSAESLISLERKKEKNINRDITSRKDLPSRTSNVERKASQQQWGRGNFTEGKVPHIRIENGAAIEEIYTFGRILGKGSFGIVIEATDKETETKWAIKKVNKEKAGSSAVKLLEREVNILKSVKHEHIIHLEQVFETPKKMYLVMELCEDGELKEILDRKGHFSENETRWIIQSLASAIAYLHNNDIVHRDLKLENIMVKSSLIDDNNEINLNIKVTDFGLAVKKQSRSEAMLQATCGTPIYMAPEVISAHDYSQQCDIWSIGVVMYMLLRGEPPFLASSEEKLFELIRKGELHFENAVWNSISDCAKSVLKQLMKVDPAHRITAKELLDNQWLTGNKLSSVRPTNVLEMMKEWKNNPESVEENTTEEKNKPSTEEKLKSYQPWGNVPDANYTSDEEEEKQSTAYEKQFPATSKDNFDMCSSSFTSSKLLPAEIKGEMEKTPVTPSQGTATKYPAKSGALSRTKKKL
  
Inhibitor
Name:
BDBM50400683
Synonyms:
CHEMBL2203529
Type:
Small organic molecule
Emp. Form.:
C20H14N4O2
Mol. Mass.:
342.3508
SMILES:
O=C(Nc1ccccc1-c1nc2ccccc2[nH]c1=O)c1cccnc1
Structure:
Search PDB for entries with ligand similarity: