Target
Casein kinase I isoform alpha
Ligand
BDBM50400749
Substrate
n/a
Meas. Tech.
ChEMBL_880534 (CHEMBL2211469)
IC50
19±n/a nM
Citation
 Huang, HAcquaviva, LBerry, VBregman, HChakka, NDiMauro, EFDovey, JEpstein, OGrubinska, BGoldstein, JGunaydin, HHua, ZHuang, XHuang, LHuman, JLong, ANewcomb, JPatel, VFSaffran, DSerafino, RSchneider, SStrathdee, CTang, JTurci, SWhite, RYu, VZhao, HWilson, CMartin, MW Structure-Based Design of Potent and Selective CK1¿ Inhibitors. ACS Med Chem Lett 3:1059-1064 (2012) [PubMed]  Article 
Target
Name:
Casein kinase I isoform alpha
Synonyms:
CK1 | CKI-alpha | CSNK1A1 | Casein Kinase I | Casein kinase 1 alpha (CK1 alpha) | Casein kinase I isoform alpha/delta | KC1A_HUMAN
Type:
Serine/threonine-protein kinase
Mol. Mass.:
38936.59
Organism:
Homo sapiens (Human)
Description:
P48729
Residue:
337
Sequence:
MASSSGSKAEFIVGGKYKLVRKIGSGSFGDIYLAINITNGEEVAVKLESQKARHPQLLYESKLYKILQGGVGIPHIRWYGQEKDYNVLVMDLLGPSLEDLFNFCSRRFTMKTVLMLADQMISRIEYVHTKNFIHRDIKPDNFLMGIGRHCNKLFLIDFGLAKKYRDNRTRQHIPYREDKNLTGTARYASINAHLGIEQSRRDDMESLGYVLMYFNRTSLPWQGLKAATKKQKYEKISEKKMSTPVEVLCKGFPAEFAMYLNYCRGLRFEEAPDYMYLRQLFRILFRTLNHQYDYTFDWTMLKQKAAQQAASSSGQGQQAQTPTGKQTDKTKSNMKGF
  
Inhibitor
Name:
BDBM50400749
Synonyms:
CHEMBL2203555
Type:
Small organic molecule
Emp. Form.:
C19H19N5O2
Mol. Mass.:
349.3865
SMILES:
COc1cnc(NCc2ccccc2)nc1-c1cc2c(CCNC2=O)[nH]1
Structure:
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