Reaction Details Report a problem with these data
Target
Type-2 angiotensin II receptor
Ligand
BDBM50281630
Substrate
n/a
Meas. Tech.
ChEMBL_879302 (CHEMBL2208700)
IC50
100±n/a nM
Citation
 Meanwell, NA Synopsis of some recent tactical application of bioisosteres in drug design. J Med Chem 54:2529-91 (2011) [PubMed]  Article 
Target
Name:
Type-2 angiotensin II receptor
Synonyms:
AGTR2 | AGTR2_HUMAN | AT2 | Angiotensin II receptor | Angiotensin II type 2 (AT-2) receptor | Angiotensin II, central | Type-2 angiotensin II receptor
Type:
Enzyme Catalytic Domain
Mol. Mass.:
41201.61
Organism:
Homo sapiens (Human)
Description:
Angiotensin II, central 0 0::P50052
Residue:
363
Sequence:
MKGNSTLATTSKNITSGLHFGLVNISGNNESTLNCSQKPSDKHLDAIPILYYIIFVIGFLVNIVVVTLFCCQKGPKKVSSIYIFNLAVADLLLLATLPLWATYYSYRYDWLFGPVMCKVFGSFLTLNMFASIFFITCMSVDRYQSVIYPFLSQRRNPWQASYIVPLVWCMACLSSLPTFYFRDVRTIEYLGVNACIMAFPPEKYAQWSAGIALMKNILGFIIPLIFIATCYFGIRKHLLKTNSYGKNRITRDQVLKMAAAVVLAFIICWLPFHVLTFLDALAWMGVINSCEVIAVIDLALPFAILLGFTNSCVNPFLYCFVGNRFQQKLRSVFRVPITWLQGKRESMSCRKSSSLREMETFVS
  
Inhibitor
Name:
BDBM50281630
Synonyms:
C,C,C-Trifluoro-N-{4'-[(2-trifluoromethyl-5,6,7,8-tetrahydro-quinazolin-4-ylamino)-methyl]-biphenyl-2-yl}-methanesulfonamide | CHEMBL165572
Type:
Small organic molecule
Emp. Form.:
C23H20F6N4O2S
Mol. Mass.:
530.486
SMILES:
FC(F)(F)c1nc2CCCCc2c(NCc2ccc(cc2)-c2ccccc2NS(=O)(=O)C(F)(F)F)n1
Structure:
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