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Target
Neuropeptides B/W receptor type 1
Ligand
BDBM75907
Substrate
n/a
Meas. Tech.
ChEMBL_887068 (CHEMBL2213859)
IC50
5600±n/a nM
Citation
 Urbano, M; Guerrero, M; Zhao, J; Velaparthi, S; Saldanha, SA; Chase, P; Wang, Z; Civelli, O; Hodder, P; Schaeffer, MT; Brown, S; Rosen, H; Roberts, E Design, synthesis and SAR analysis of novel potent and selective small molecule antagonists of NPBWR1 (GPR7). Bioorg Med Chem Lett 22:7135-41 (2012) [PubMed]  Article 
Target
Name:
Neuropeptides B/W receptor type 1
Synonyms:
GPR7 | NPBW1_HUMAN | NPBWR1 | neuropeptides B/W receptor 1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
36111.82
Organism:
Homo sapiens (Human)
Description:
gi_119607128
Residue:
328
Sequence:
MDNASFSEPWPANASGPDPALSCSNASTLAPLPAPLAVAVPVVYAVICAVGLAGNSAVLYVLLRAPRMKTVTNLFILNLAIADELFTLVLPINIADFLLRQWPFGELMCKLIVAIDQYNTFSSLYFLTVMSADRYLVVLATAESRRVAGRTYSAARAVSLAVWGIVTLVVLPFAVFARLDDEQGRRQCVLVFPQPEAFWWRASRLYTLVLGFAIPVSTICVLYTTLLCRLHAMRLDSHAKALERAKKRVTFLVVAILAVCLLCWTPYHLSTVVALTTDLPQTPLVIAISYFITSLSYANSCLNPFLYAFLDASFRRNLRQLITCRAAA
  
Inhibitor
Name:
BDBM75907
Synonyms:
4-(4-methoxyphenoxy)-5-methylol-2-p-cumenyl-pyridazin-3-one | 5-(hydroxymethyl)-4-(4-methoxyphenoxy)-2-(4-propan-2-ylphenyl)-3-pyridazinone | 5-(hydroxymethyl)-4-(4-methoxyphenoxy)-2-(4-propan-2-ylphenyl)pyridazin-3-one | SR-02000000429 | SR-02000000429-1 | cid_46835804
Type:
Small organic molecule
Emp. Form.:
C21H22N2O4
Mol. Mass.:
366.4104
SMILES:
COc1ccc(Oc2c(CO)cnn(-c3ccc(cc3)C(C)C)c2=O)cc1
Structure:
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