Reaction Details Report a problem with these data
Target
C-C chemokine receptor type 3
Ligand
BDBM50402126
Substrate
n/a
Meas. Tech.
ChEMBL_884699 (CHEMBL2215147)
Ki
2.51±n/a nM
Citation
 Furber, M; Alcaraz, L; Luckhurst, C; Bahl, A; Beaton, H; Bowers, K; Collington, J; Denton, R; Donald, D; Kinchin, E; MacDonald, C; Rigby, A; Riley, R; Soars, M; Springthorpe, B; Webborn, P Discovery and evolution of phenoxypiperidine hydroxyamide dual CCR3/H1 antagonists. Part II: optimising in vivo clearance. Bioorg Med Chem Lett 22:7707-10 (2012) [PubMed]  Article 
Target
Name:
C-C chemokine receptor type 3
Synonyms:
C-C CKR-3 | C-C chemokine receptor type 3 (CCR3) | CC-CKR-3 | CCR-3 | CCR3 | CCR3_HUMAN | CD_antigen=CD193 | CKR3 | CMKBR3 | Eosinophil eotaxin receptor
Type:
Enzyme
Mol. Mass.:
41053.88
Organism:
Homo sapiens (Human)
Description:
P51677
Residue:
355
Sequence:
MTTSLDTVETFGTTSYYDDVGLLCEKADTRALMAQFVPPLYSLVFTVGLLGNVVVVMILIKYRRLRIMTNIYLLNLAISDLLFLVTLPFWIHYVRGHNWVFGHGMCKLLSGFYHTGLYSEIFFIILLTIDRYLAIVHAVFALRARTVTFGVITSIVTWGLAVLAALPEFIFYETEELFEETLCSALYPEDTVYSWRHFHTLRMTIFCLVLPLLVMAICYTGIIKTLLRCPSKKKYKAIRLIFVIMAVFFIFWTPYNVAILLSSYQSILFGNDCERSKHLDLVMLVTEVIAYSHCCMNPVIYAFVGERFRKYLRHFFHRHLLMHLGRYIPFLPSEKLERTSSVSPSTAEPELSIVF
  
Inhibitor
Name:
BDBM50402126
Synonyms:
CHEMBL2207672
Type:
Small organic molecule
Emp. Form.:
C26H29Cl2N3O6S
Mol. Mass.:
582.496
SMILES:
Cc1c(Cl)ccc(OC2CCN(C[C@H](O)CNC(=O)c3c[nH]c(=O)c4cc(ccc34)S(C)(=O)=O)CC2)c1Cl |r|
Structure:
Search PDB for entries with ligand similarity: