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TargetHistamine H1 receptor
LigandBDBM50402814
Substrate/Competitorn/a
Meas. Tech.ChEMBL_887254
Ki 3.16±n/a nM
Citation Furber, MAlcaraz, LLuckhurst, CBahl, ABeaton, HBowers, KCollington, JDenton, RDonald, DKinchin, EMacDonald, CRigby, ARiley, RSoars, MSpringthorpe, BWebborn, P Discovery and evolution of phenoxypiperidine hydroxyamide dual CCR3/H1 antagonists. Part I. Bioorg Med Chem Lett22:7702-6 (2012) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Histamine H1 receptor
Name:Histamine H1 receptor
Synonyms:H1R | HH1R | HISTAMINE H1 | HRH1
Type:G Protein-Coupled Receptor (GPCR)
Mol. Mass.:55808.72
Organism:Homo sapiens (Human)
Description:Cell pellets from SK-N-MC cells transfected with human H1 receptor were used in binding assay.
Residue:487
Sequence:
MSLPNSSCLLEDKMCEGNKTTMASPQLMPLVVVLSTICLVTVGLNLLVLYAVRSERKLHT
VGNLYIVSLSVADLIVGAVVMPMNILYLLMSKWSLGRPLCLFWLSMDYVASTASIFSVFI
LCIDRYRSVQQPLRYLKYRTKTRASATILGAWFLSFLWVIPILGWNHFMQQTSVRREDKC
ETDFYDVTWFKVMTAIINFYLPTLLMLWFYAKIYKAVRQHCQHRELINRSLPSFSEIKLR
PENPKGDAKKPGKESPWEVLKRKPKDAGGGSVLKSPSQTPKEMKSPVVFSQEDDREVDKL
YCFPLDIVHMQAAAEGSSRDYVAVNRSHGQLKTDEQGLNTHGASEISEDQMLGDSQSFSR
TDSDTTTETAPGKGKLRSGSNTGLDYIKFTWKRLRSHSRQYVSGLHMNRERKAAKQLGFI
MAAFILCWIPYFIFFMVIAFCKNCCNEHLHMFTIWLGYINSTLNPLIYPLCNENFKKTFK
RILHIRS
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  Blast E-value cutoff:
BDBM50402814
NameBDBM50402814
Synonyms:CHEMBL2208419
TypeSmall organic molecule
Emp. Form.C21H22Cl2N2O3
Mol. Mass.421.317
SMILESO[C@H](COc1cccc(c1)C#N)CN1CCC(CC1)Oc1ccc(Cl)c(Cl)c1 |r|
Structure
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n/a