| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Adrenergic receptor alpha |
|---|
| Ligand | BDBM50403737 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_32528 |
|---|
| IC50 | 11±n/a nM |
|---|
| Citation |  Kennis, LE; Bischoff, FP; Mertens, CJ; Love, CJ; Van den Keybus, FA; Pieters, S; Braeken, M; Megens, AA; Leysen, JE New 2-substituted 1,2,3,4-tetrahydrobenzofuro[3,2-c]pyridine having highly active and potent central alpha 2-antagonistic activity as potential antidepressants. Bioorg Med Chem Lett10:71-4 (2000) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Adrenergic receptor alpha |
|---|
| Name: | Adrenergic receptor alpha |
|---|
| Synonyms: | ADRA2B | ADRA2L1 | ADRA2RL1 | Alpha-2 adrenergic receptor subtype C2 | Alpha-2B adrenergic receptor | Alpha-2B adrenoceptor | Alpha-2B adrenoreceptor | Alpha-2BAR |
|---|
| Type: | PROTEIN |
|---|
| Mol. Mass.: | 49964.20 |
|---|
| Organism: | Homo sapiens |
|---|
| Description: | ChEMBL_104787 |
|---|
| Residue: | 450 |
|---|
| Sequence: | MDHQDPYSVQATAAIAAAITFLILFTIFGNALVILAVLTSRSLRAPQNLFLVSLAAADIL
VATLIIPFSLANELLGYWYFRRTWCEVYLALDVLFCTSSIVHLCAISLDRYWAVSRALEY
NSKRTPRRIKCIILTVWLIAAVISLPPLIYKGDQGPQPRGRPQCKLNQEAWYILASSIGS
FFAPCLIMILVYLRIYLIAKRSNRRGPRAKGGPGQGESKQPRPDHGGALASAKLPALASV
ASAREVNGHSKSTGEKEEGETPEDTGTRALPPSWAALPNSGQGQKEGVCGASPEDEAEEE
EEEEEEEEECEPQAVPVSPASACSPPLQQPQGSRVLATLRGQVLLGRGVGAIGGQWWRRR
AQLTREKRFTFVLAVVIGVFVLCWFPFFFSYSLGAICPKHCKVPHGLFQFFFWIGYCNSS
LNPVIYTIFNQDFRRAFRRILCRPWTQTAW
|
|
|
|---|
| BDBM50403737 |
|---|
| Name | BDBM50403737 |
|---|
| Synonyms: | CHEMBL165776 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C23H23N3O2 |
|---|
| Mol. Mass. | 373.4476 |
|---|
| SMILES | Cc1nc2ccccn2c(=O)c1CCCN1CCc2oc3ccccc3c2C1 |
|---|
| Structure | 
|
|---|
| n/a |
|---|
Search and Browse
