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Target
Inosine-5'-monophosphate dehydrogenase 2
Ligand
BDBM50019477
Substrate
n/a
Meas. Tech.
ChEBML_89794
Ki
17000±n/a nM
Citation
 Marquez, VE; Tseng, CK; Gebeyehu, G; Cooney, DA; Ahluwalia, GS; Kelley, JA; Dalal, M; Fuller, RW; Wilson, YA; Johns, DG Thiazole-4-carboxamide adenine dinucleotide (TAD). Analogues stable to phosphodiesterase hydrolysis. J Med Chem 29:1726-31 (1986) [PubMed]  Article 
Target
Name:
Inosine-5'-monophosphate dehydrogenase 2
Synonyms:
IMDH2_MOUSE | Impdh2
Type:
PROTEIN
Mol. Mass.:
55818.95
Organism:
Mus musculus
Description:
ChEMBL_1297303
Residue:
514
Sequence:
MADYLISGGTSYVPDDGLTAQQLFNCGDGLTYNDFLILPGYIDFTADQVDLTSALTKKITLKTPLVSSPMDTVTEAGMAIAMALTGGIGFIHHNCTPEFQANEVRKVKKYEQGFITDPVVLSPKDRVRDVFEAKARHGFCGIPITDTGRMGSRLVGIISSRDIDFLKEEEHDRFLEEIMTKREDLVVAPAGVTLKEANEILQRSKKGKLPIVNENDELVAIIARTDLKKNRDYPLASKDAKKQLLCGAAIGTHEDDKYRLDLLALAGVDVVVLDSSQGNSIFQINMIKYIKEKYPSLQVIGGNVVTAAQAKNLIDAGVDALRVGMGSGSICITQEVLACGRPQATAVYKVSEYARRFGVPVIADGGIQNVGHIAKALALGASTVMMGSLLAATTEAPGEYFFSDGIRLKKYRGMGSLDAMDKHLSSQNRYFSEADKIKVAQGVSGAVQDKGSIHKFVPYLIAGIQHSCQDIGAKSLTQVRAMMYSGELKFEKRTSSAQVEGGVHSLHSYEKRLF
  
Inhibitor
Name:
BDBM50019477
Synonyms:
CHEMBL3144394 | gama-methylene-Thiazole-4-carboxamide adenine dinucleotide
Type:
Small organic molecule
Emp. Form.:
C20H27N7O13P2S
Mol. Mass.:
667.48
SMILES:
NC(=O)c1csc(n1)[C@@H]1O[C@H](COP(O)(=O)OP(O)(=O)CC[C@H]2O[C@H]([C@H](O)[C@@H]2O)n2cnc3c(N)ncnc23)[C@@H](O)[C@H]1O |r|
Structure:
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