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TargetBeta-1 adrenergic receptor
LigandBDBM25749
Substrate/Competitorn/a
Meas. Tech.ChEMBL_39342
Kd 8318±n/a nM
Citation Manoury, PMBinet, JLRousseau, JLefèvre-Borg, FCavero, IG Synthesis of a series of compounds related to betaxolol, a new beta 1-adrenoceptor antagonist with a pharmacological and pharmacokinetic profile optimized for the treatment of chronic cardiovascular diseases. J Med Chem30:1003-11 (1987) [PubMed]  Article
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Beta-1 adrenergic receptor
Name:Beta-1 adrenergic receptor
Synonyms:ADRB1 | Adrenergic receptor | adrenergic Beta1
Type:Enzyme Catalytic Domain
Mol. Mass.:50540.48
Organism:GUINEA PIG
Description:adrenergic Beta1 ADRB1 GUINEA PIG::B0FL73
Residue:467
Sequence:
MGAGVLALGASEPCNLSSTAPLPDGAATAARLLVPASPPASLLPPTSEGSEPLSPQWTAG
MGLLMVLIVLLIVAGNVLVIVAIAKTPRLQTLTNLFIMSLASADLVMGLLVVPFGATIVV
WGRWEYGSFFCELWTSVDVLCVTASIETLCVIALDRYLAITSPFRYQSLLTRARARVLVC
TVWAISALVSFLPILMHWWRAEGDEARRCYNDPKCCDFVTNRAYAIASSVVSFYVPLCIM
AFVYLRVFREAQKQVKKIDSCERRFLGGPGRPPSPVPSPTPGSPRAATDPLANGRTSKRR
PSRLVALREQKALKTLGIIMGVFTLCWLPFFLANVVKAFHRDLVPDRLFVFFNWLGYANS
AFNPIIYCRSPDFRKAFQRLLCCARRAARRRHTAHGGRPRASGCLARSGPPPSPGAASDE
DEDAVGAAPPARLLEPWAGCNGGAATADSDWSLDEPGRAGFASESKV
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  Blast E-value cutoff:
BDBM25749
NameBDBM25749
Synonyms:CHEMBL6995 | N-{4-[2-hydroxy-3-(propan-2-ylamino)propoxy]phenyl}acetamide | Practolol | Practolol,(+) | Practolol,(-)
TypeSmall organic molecule
Emp. Form.C14H22N2O3
Mol. Mass.266.3361
SMILESCC(C)NCC(O)COc1ccc(NC(C)=O)cc1
Structure
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n/a