Target
Dihydrofolate reductase
Ligand
BDBM50405956
Substrate
n/a
Meas. Tech.
ChEBML_53614
Ki
25704±n/a nM
Citation
 Selassie, CDFang, ZXLi, RLHansch, CDebnath, GKlein, TELangridge, RKaufman, BT On the structure selectivity problem in drug design. A comparative study of benzylpyrimidine inhibition of vertebrate and bacterial dihydrofolate reductase via molecular graphics and quantitative structure-activity relationships. J Med Chem 32:1895-905 (1989) [PubMed]  Article 
Target
Name:
Dihydrofolate reductase
Synonyms:
1.5.1.3 | DHFR | DYR_CHICK
Type:
n/a
Mol. Mass.:
21652.69
Organism:
Gallus gallus (Chicken)
Description:
n/a
Residue:
189
Sequence:
VRSLNSIVAVCQNMGIGKDGNLPWPPLRNEYKYFQRMTSTSHVEGKQNAVIMGKKTWFSIPEKNRPLKDRINIVLSRELKEAPKGAHYLSKSLDDALALLDSPELKSKVDMVWIVGGTAVYKAAMEKPINHRLFVTRILHEFESDTFFPEIDYKDFKLLTEYPGVPADIQEEDGIQYKFEVYQKSVLAQ
  
Inhibitor
Name:
BDBM50405956
Synonyms:
CHEMBL57383
Type:
Small organic molecule
Emp. Form.:
C13H16N4O4S
Mol. Mass.:
324.356
SMILES:
COc1cc(Cc2cnc(N)nc2N)ccc1OS(C)(=O)=O
Structure:
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