Reaction Details Report a problem with these data
Target
Translocator protein
Ligand
BDBM50040706
Substrate
n/a
Meas. Tech.
ChEMBL_38119 (CHEMBL650074)
IC50
277000000±n/a nM
Citation
 So, SS; Karplus, M Genetic neural networks for quantitative structure-activity relationships: improvements and application of benzodiazepine affinity for benzodiazepine/GABAA receptors. J Med Chem 39:5246-56 (1997) [PubMed]  Article 
Target
Name:
Translocator protein
Synonyms:
BZRP | MBR | Mitochondrial benzodiazepine receptor | PBR | PKBS | Peripheral benzodiazepine receptor-related protein | Peripheral-type benzodiazepine receptor | TSPO | TSPO_HUMAN
Type:
Enzyme
Mol. Mass.:
18834.74
Organism:
Homo sapiens (Human)
Description:
P30536
Residue:
169
Sequence:
MAPPWVPAMGFTLAPSLGCFVGSRFVHGEGLRWYAGLQKPSWHPPHWVLGPVWGTLYSAMGYGSYLVWKELGGFTEKAVVPLGLYTGQLALNWAWPPIFFGARQMGWALVDLLLVSGAAAATTVAWYQVSPLAARLLYPYLAWLAFTTTLNYCVWRDNHGWRGGRRLPE
  
Inhibitor
Name:
BDBM50040706
Synonyms:
7,8-Dichloro-5-(2-fluoro-phenyl)-1,3-dihydro-benzo[e][1,4]diazepin-2-one | CHEMBL443823 | Ro-20-8065
Type:
Small organic molecule
Emp. Form.:
C15H9Cl2FN2O
Mol. Mass.:
323.149
SMILES:
Fc1ccccc1C1=NCC(=O)Nc2cc(Cl)c(Cl)cc12 |t:8|
Structure:
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