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TargetCerebral cortex alpha adrenergic receptor
LigandBDBM50408225
Substrate/Competitorn/a
Meas. Tech.ChEMBL_33595
Ki 3.2±n/a nM
Citation Elworthy, TRFord, APBantle, GWMorgans, DJOzer, RSPalmer, WSRepke, DBRomero, MSandoval, LSjogren, EBTalamás, FXVazquez, AWu, HArredondo, NFBlue, DRDeSousa, AGross, LMKava, MSLesnick, JDVimont, RLWilliams, TJZhu, QMPfister, JRClarke, DE N-arylpiperazinyl-N'-propylamino derivatives of heteroaryl amides as functional uroselective alpha 1-adrenoceptor antagonists. J Med Chem40:2674-87 (1997) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Cerebral cortex alpha adrenergic receptor
Name:Cerebral cortex alpha adrenergic receptor
Synonyms:Alpha 1A-adrenoceptor | Alpha 1A-adrenoreceptor | Alpha-1C adrenergic receptor | Cerebral cortex alpha adrenergic receptor | adrenergic Alpha1
Type:Enzyme Catalytic Domain
Mol. Mass.:51492.08
Organism:CALF
Description:adrenergic Alpha1 0 CALF
Residue:466
Sequence:
MVFLSGNASDSSNCTHPPPPVNISKAILLGVILGGLILFGVLGNILVILSVACHRHLHSV
THYYIVNLAVADLLLTSTVLPFSAIFEILGYWAFGRVFCNVWAAVDVLCCTASIMGLCII
SIDRYIGVSYPLRYPTIVTQKRGLMALLCVWALSLVISIGPLFGWRQPAPEDETICQINE
EPGYVLFSALGSFYVPLTIILVMYCRVYVVAKRESRGLKSGLKTDKSDSEQVTLRIHRKN
AQVGGSGVTSAKNKTHFSVRLLKFSREKKAAKTLGIVVGCFVLCWLPFFLVMPIGSFFPD
FRPSETVFKIAFWLGYLNSCINPIIYPCSSQEFKKAFQNVLRIQCLRRKQSSKHTLGYTL
HAPSHVLEGQHKDLVRIPVGSAETFYKISKTDGVCEWKIFSSLPRGSARMAVARDPSACT
TARVRSKSFLQVCCCLGPSTPSHGENHQIPTIKIHTISLSENGEEV
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50408225
NameBDBM50408225
Synonyms:CHEMBL312935
TypeSmall organic molecule
Emp. Form.C23H32N4O3
Mol. Mass.412.5252
SMILESCCOc1ccccc1OCCNC1CCN(CC1)c1ncccc1C(=O)N(C)C
Structure
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