Reaction Details Report a problem with these data
Target
ATP synthase subunit gamma, mitochondrial
Ligand
BDBM50409911
Substrate
n/a
Meas. Tech.
ChEMBL_65923 (CHEMBL678318)
IC50
45000±n/a nM
Citation
 Atwal, KS; Wang, P; Rogers, WL; Sleph, P; Monshizadegan, H; Ferrara, FN; Traeger, S; Green, DW; Grover, GJ Small molecule mitochondrial F1F0 ATPase hydrolase inhibitors as cardioprotective agents. Identification of 4-(N-arylimidazole)-substituted benzopyran derivatives as selective hydrolase inhibitors. J Med Chem 47:1081-4 (2004) [PubMed]  Article 
Target
Name:
ATP synthase subunit gamma, mitochondrial
Synonyms:
ATP5C | ATP5C1 | ATP5F1C | ATPG_BOVIN | F-ATPase gamma subunit
Type:
PROTEIN
Mol. Mass.:
33081.70
Organism:
Bos taurus
Description:
ChEMBL_65923
Residue:
298
Sequence:
MFSRAGVAGLSAWTVQPQWIQVRNMATLKDITRRLKSIKNIQKITKSMKMVAAAKYARAERELKPARVYGVGSLALYEKADIKTPEDKKKHLIIGVSSDRGLCGAIHSSVAKQMKSEAANLAAAGKEVKIIGVGDKIRSILHRTHSDQFLVTFKEVGRRPPTFGDASVIALELLNSGYEFDEGSIIFNRFRSVISYKTEEKPIFSLDTISSAESMSIYDDIDADVLRNYQEYSLANIIYYSLKESTTSEQSARMTAMDNASKNASEMIDKLTLTFNRTRQAVITKELIEIISGAAALD
  
Inhibitor
Name:
BDBM50409911
Synonyms:
CHEMBL274443
Type:
Small organic molecule
Emp. Form.:
C18H17ClN2O2
Mol. Mass.:
328.793
SMILES:
CC1(C)Oc2ccc(cc2C(Nc2ccc(Cl)cc2)C1O)C#N
Structure:
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