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TargetAnti-estrogen binding site (AEBS)
LigandBDBM50412082
Substrate/Competitorn/a
Meas. Tech.ChEMBL_550766
IC50 600±n/a nM
Citation Chang, LCBhat, KPPisha, EKennelly, EJFong, HHPezzuto, JMKinghorn, AD Activity-guided isolation of steroidal alkaloid antiestrogen-binding site inhibitors from Pachysandra procumbens. J Nat Prod61:1257-62 (1998) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Anti-estrogen binding site (AEBS)
Name:Anti-estrogen binding site (AEBS)
Synonyms:7-DHC reductase | 7-dehydrocholesterol reductase | D7SR | DHCR7 | Putative sterol reductase SR-2 | Sterol Delta(7)-reductase
Type:PROTEIN
Mol. Mass.:54508.42
Organism:Homo sapiens (Human)
Description:ChEMBL_864350
Residue:475
Sequence:
MAAKSQPNIPKAKSLDGVTNDRTASQGQWGRAWEVDWFSLASVIFLLLFAPFIVYYFIMA
CDQYSCALTGPVVDIVTGHARLSDIWAKTPPITRKAAQLYTLWVTFQVLLYTSLPDFCHK
FLPGYVGGIQEGAVTPAGVVNKYQINGLQAWLLTHLLWFANAHLLSWFSPTIIFDNWIPL
LWCANILGYAVSTFAMVKGYFFPTSARDCKFTGNFFYNYMMGIEFNPRIGKWFDFKLFFN
GRPGIVAWTLINLSFAAKQRELHSHVTNAMVLVNVLQAIYVIDFFWNETWYLKTIDICHD
HFGWYLGWGDCVWLPYLYTLQGLYLVYHPVQLSTPHAVGVLLLGLVGYYIFRVANHQKDL
FRRTDGRCLIWGRKPKVIECSYTSADGQRHHSKLLVSGFWGVARHFNYVGDLMGSLAYCL
ACGGGHLLPYFYIIYMAILLTHRCLRDEHRCASKYGRDWERYTAAVPYRLLPGIF
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  Blast E-value cutoff:
BDBM50412082
NameBDBM50412082
Synonyms:CHEMBL455316
TypeSmall organic molecule
Emp. Form.C32H46N2O3
Mol. Mass.506.7192
SMILESC[C@@H]([C@H]1CC[C@H]2[C@@H]3CC[C@H]4[C@@H](OC(C)=O)C(NC(=O)c5ccccc5)=CC[C@]4(C)[C@H]3CC[C@]12C)N(C)C |r,c:25|
Structure
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