Reaction Details Report a problem with these data
Target
Histamine H3 receptor
Ligand
BDBM50401007
Substrate
n/a
Meas. Tech.
ChEMBL_536770 (CHEMBL984564)
Ki
6.61±n/a nM
Citation
 Morini, G; Comini, M; Rivara, M; Rivara, S; Bordi, F; Plazzi, PV; Flammini, L; Saccani, F; Bertoni, S; Ballabeni, V; Barocelli, E; Mor, M Synthesis and structure-activity relationships for biphenyl H3 receptor antagonists with moderate anti-cholinesterase activity. Bioorg Med Chem 16:9911-24 (2008) [PubMed]  Article 
Target
Name:
Histamine H3 receptor
Synonyms:
HH3R | HRH3_RAT | Hrh3
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
48607.98
Organism:
Rattus norvegicus (rat)
Description:
n/a
Residue:
445
Sequence:
MERAPPDGLMNASGTLAGEAAAAGGARGFSAAWTAVLAALMALLIVATVLGNALVMLAFVADSSLRTQNNFFLLNLAISDFLVGAFCIPLYVPYVLTGRWTFGRGLCKLWLVVDYLLCASSVFNIVLISYDRFLSVTRAVSYRAQQGDTRRAVRKMALVWVLAFLLYGPAILSWEYLSGGSSIPEGHCYAEFFYNWYFLITASTLEFFTPFLSVTFFNLSIYLNIQRRTRLRLDGGREAGPEPPPDAQPSPPPAPPSCWGCWPKGHGEAMPLHRYGVGEAGPGVEAGEAALGGGSGGGAAASPTSSSGSSSRGTERPRSLKRGSKPSASSASLEKRMKMVSQSITQRFRLSRDKKVAKSLAIIVSIFGLCWAPYTLLMIIRAACHGRCIPDYWYETSFWLLWANSAVNPVLYPLCHYSFRRAFTKLLCPQKLKVQPHGSLEQCWK
  
Inhibitor
Name:
BDBM50401007
Synonyms:
CHEMBL209478
Type:
Small organic molecule
Emp. Form.:
C18H24N2
Mol. Mass.:
268.3966
SMILES:
CN(C)Cc1ccc(cc1)-c1ccc(CN(C)C)cc1
Structure:
Search PDB for entries with ligand similarity: