Target
P2X purinoceptor 7
Ligand
BDBM50414304
Substrate
n/a
Meas. Tech.
ChEMBL_574385 (CHEMBL1028693)
IC50
0.0501±n/a nM
Citation
 Guile, SDAlcaraz, LBirkinshaw, TNBowers, KCEbden, MRFurber, MStocks, MJ Antagonists of the P2X(7) receptor. From lead identification to drug development. J Med Chem 52:3123-41 (2009) [PubMed]  Article 
Target
Name:
P2X purinoceptor 7
Synonyms:
ATP receptor | P2RX7 | P2RX7_HUMAN | P2X purinoceptor 7 (P2RX7) | P2X purinoceptor 7 (P2X7) | P2X7 | P2Z receptor | Purinergic receptor
Type:
Protein
Mol. Mass.:
68602.85
Organism:
Homo sapiens (Human)
Description:
Q99572
Residue:
595
Sequence:
MPACCSCSDVFQYETNKVTRIQSMNYGTIKWFFHVIIFSYVCFALVSDKLYQRKEPVISSVHTKVKGIAEVKEEIVENGVKKLVHSVFDTADYTFPLQGNSFFVMTNFLKTEGQEQRLCPEYPTRRTLCSSDRGCKKGWMDPQSKGIQTGRCVVYEGNQKTCEVSAWCPIEAVEEAPRPALLNSAENFTVLIKNNIDFPGHNYTTRNILPGLNITCTFHKTQNPQCPIFRLGDIFRETGDNFSDVAIQGGIMGIEIYWDCNLDRWFHHCRPKYSFRRLDDKTTNVSLYPGYNFRYAKYYKENNVEKRTLIKVFGIRFDILVFGTGGKFDIIQLVVYIGSTLSYFGLAAVFIDFLIDTYSSNCCRSHIYPWCKCCQPCVVNEYYYRKKCESIVEPKPTLKYVSFVDESHIRMVNQQLLGRSLQDVKGQEVPRPAMDFTDLSRLPLALHDTPPIPGQPEEIQLLRKEATPRSRDSPVWCQCGSCLPSQLPESHRCLEELCCRKKPGACITTSELFRKLVLSRHVLQFLLLYQEPLLALDVDSTNSRLRHCAYRCYATWRFGSQDMADFAILPSCCRWRIRKEFPKSEGQYSGFKSPY
  
Inhibitor
Name:
BDBM50414304
Synonyms:
CHEMBL550030
Type:
Small organic molecule
Emp. Form.:
C26H34N2O3
Mol. Mass.:
422.5598
SMILES:
CC(C)C(CO)n1ccc2c(NC(=O)CC34CC5CC(CC(C5)C3)C4)cccc2c1=O |TLB:16:15:18.17.22:20,22:17:24:21.20.23,22:21:24:18.17.16,14:15:18.17.22:20,THB:16:17:20:24.15.23,14:15:18:22.21.20,23:15:18:22.21.20,23:21:18:24.16.15|
Structure:
Search PDB for entries with ligand similarity: