Reaction Details Report a problem with these data
Target
Sigma non-opioid intracellular receptor 1
Ligand
BDBM50064172
Substrate
n/a
Meas. Tech.
ChEMBL_595183 (CHEMBL1040025)
Ki
0.589±n/a nM
Citation
 Piergentili, A; Amantini, C; Del Bello, F; Giannella, M; Mattioli, L; Palmery, M; Perfumi, M; Pigini, M; Santoni, G; Tucci, P; Zotti, M; Quaglia, W Novel highly potent and selective sigma 1 receptor antagonists related to spipethiane. J Med Chem 53:1261-9 (2010) [PubMed]  Article 
Target
Name:
Sigma non-opioid intracellular receptor 1
Synonyms:
Aging-associated gene 8 protein | OPRS1 | SGMR1_HUMAN | SIG-1R | SIGMAR1 | SR-BP | SR31747-binding protein | SRBP | Sigma 1-type opioid receptor | Sigma opioid receptor | Sigma1R | hSigmaR1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
25124.85
Organism:
Homo sapiens (Human)
Description:
Q99720
Residue:
223
Sequence:
MQWAVGRRWAWAALLLAVAAVLTQVVWLWLGTQSFVFQREEIAQLARQYAGLDHELAFSRLIVELRRLHPGHVLPDEELQWVFVNAGGWMGAMCLLHASLSEYVLLFGTALGSRGHSGRYWAEISDTIISGTFHQWREGTTKSEVFYPGETVVHGPGEATAVEWGPNTWMVEYGRGVIPSTLAFALADTVFSTQDFLTLFYTLRSYARGLRLELTTYLFGQDP
  
Inhibitor
Name:
BDBM50064172
Synonyms:
1-benzylspiro[hexahydropyridine-4,2'-(3',4'-dihydro-2'H-thiochromene)] | CHEMBL39900 | SPIPETHIANE
Type:
Small organic molecule
Emp. Form.:
C20H23NS
Mol. Mass.:
309.468
SMILES:
C(N1CCC2(CC1)CCc1ccccc1S2)c1ccccc1
Structure:
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