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Target
Calcitonin gene-related peptide type 1 receptor
Ligand
BDBM50415355
Substrate
n/a
Meas. Tech.
ChEMBL_608969 (CHEMBL1073111)
Ki
6.31±n/a nM
Citation
 Nichols, PL; Brand, J; Briggs, M; D'Angeli, M; Farge, J; Garland, SL; Goldsmith, P; Hutchings, R; Kilford, I; Li, HY; MacPherson, D; Nimmo, F; Sanderson, FD; Sehmi, S; Shuker, N; Skidmore, J; Stott, M; Sweeting, J; Tajuddin, H; Takle, AK; Trani, G; Wall, ID; Ward, R; Wilson, DM; Witty, D Potent oxadiazole CGRP receptor antagonists for the potential treatment of migraine. Bioorg Med Chem Lett 20:1368-72 (2010) [PubMed]  Article 
Target
Name:
Calcitonin gene-related peptide type 1 receptor
Synonyms:
Adrenomedullin receptor AM1; CALCRL/RAMP2 | CALCRL | CALRL_HUMAN | CGRP type 1 receptor | CGRP type 1 receptor mRNA | CGRPR | Calcitonin gene-related peptide (CGRP) receptor | Calcitonin gene-related peptide 1 (CGRP) | Calcitonin receptor-like receptor | Calcitonin receptor-like receptor (CLR) | Human CL receptor
Type:
Enzyme Catalytic Domain
Mol. Mass.:
52980.45
Organism:
Homo sapiens (Human)
Description:
Q16602
Residue:
461
Sequence:
MEKKCTLYFLVLLPFFMILVTAELEESPEDSIQLGVTRNKIMTAQYECYQKIMQDPIQQAEGVYCNRTWDGWLCWNDVAAGTESMQLCPDYFQDFDPSEKVTKICDQDGNWFRHPASNRTWTNYTQCNVNTHEKVKTALNLFYLTIIGHGLSIASLLISLGIFFYFKSLSCQRITLHKNLFFSFVCNSVVTIIHLTAVANNQALVATNPVSCKVSQFIHLYLMGCNYFWMLCEGIYLHTLIVVAVFAEKQHLMWYYFLGWGFPLIPACIHAIARSLYYNDNCWISSDTHLLYIIHGPICAALLVNLFFLLNIVRVLITKLKVTHQAESNLYMKAVRATLILVPLLGIEFVLIPWRPEGKIAEEVYDYIMHILMHFQGLLVSTIFCFFNGEVQAILRRNWNQYKIQFGNSFSNSEALRSASYTVSTISDGPGYSHDCPSEHLNGKSIHDIENVLLKPENLYN
  
Inhibitor
Name:
BDBM50415355
Synonyms:
CHEMBL600837
Type:
Small organic molecule
Emp. Form.:
C25H26ClN7O4
Mol. Mass.:
523.971
SMILES:
Clc1cc(cc(c1)-c1nnc(CC(=O)N2CCC(CC2)n2c3cccnc3[nH]c2=O)o1)N1CCOCC1
Structure:
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