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Target
Histamine H4 receptor
Ligand
BDBM50415767
Substrate
n/a
Meas. Tech.
ChEMBL_615000 (CHEMBL1116877)
Ki
2.69±n/a nM
Citation
 Koenig, JR; Liu, H; Drizin, I; Witte, DG; Carr, TL; Manelli, AM; Milicic, I; Strakhova, MI; Miller, TR; Esbenshade, TA; Brioni, JD; Cowart, M Rigidified 2-aminopyrimidines as histamine H4 receptor antagonists: effects of substitution about the rigidifying ring. Bioorg Med Chem Lett 20:1900-4 (2010) [PubMed]  Article 
Target
Name:
Histamine H4 receptor
Synonyms:
HH4R | HRH4_RAT | Hrh4
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
44045.07
Organism:
Rattus norvegicus (rat)
Description:
Cell pellets from SK-N-MC cells transfected with rat H4 receptor were used in binding assay.
Residue:
391
Sequence:
MSESNGTDVLPLTAQVPLAFLMSLLAFAITIGNAVVILAFVADRNLRHRSNYFFLNLAISDFFVGVISIPLYIPHTLFNWNFGSGICMFWLITDYLLCTASVYSIVLISYDRYQSVSNAVRYRAQHTGILKIVAQMVAVWILAFLVNGPMILASDSWKNSTNTEECEPGFVTEWYILAITAFLEFLLPVSLVVYFSVQIYWSLWKRGSLSRCPSHAGFIATSSRGTGHSRRTGLACRTSLPGLKEPAASLHSESPRGKSSLLVSLRTHMSGSIIAFKVGSFCRSESPVLHQREHVELLRGRKLARSLAVLLSAFAICWAPYCLFTIVLSTYRRGERPKSIWYSIAFWLQWFNSLINPFLYPLCHRRFQKAFWKILCVTKQPAPSQTQSVSS
  
Inhibitor
Name:
BDBM50415767
Synonyms:
CHEMBL1077276
Type:
Small organic molecule
Emp. Form.:
C22H29N5
Mol. Mass.:
363.4992
SMILES:
Nc1nc2C(CCCCc2c(n1)N1CC2CCCNC2C1)c1ccccc1
Structure:
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