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Target
Oxysterols receptor LXR-alpha
Ligand
BDBM50415825
Substrate
n/a
Meas. Tech.
ChEMBL_625548 (CHEMBL1109728)
EC50
10±n/a nM
Citation
 Zuercher, WJ; Buckholz, RG; Campobasso, N; Collins, JL; Galardi, CM; Gampe, RT; Hyatt, SM; Merrihew, SL; Moore, JT; Oplinger, JA; Reid, PR; Spearing, PK; Stanley, TB; Stewart, EL; Willson, TM Discovery of tertiary sulfonamides as potent liver X receptor antagonists. J Med Chem 53:3412-6 (2010) [PubMed]  Article 
Target
Name:
Oxysterols receptor LXR-alpha
Synonyms:
LXRA | Liver X Receptor alpha (LXR-alpha) | Liver X receptor alpha | Liver X receptor alpha (LXRA) | Liver X receptor alpha (NR1H3) | Liver X, LXR alpha | NR1H3 | NR1H3_HUMAN | Nuclear orphan receptor LXR-alpha | Nuclear receptor subfamily 1 group H member 3
Type:
Enzyme Catalytic Domain
Mol. Mass.:
50403.85
Organism:
Homo sapiens (Human)
Description:
Q13133
Residue:
447
Sequence:
MSLWLGAPVPDIPPDSAVELWKPGAQDASSQAQGGSSCILREEARMPHSAGGTAGVGLEAAEPTALLTRAEPPSEPTEIRPQKRKKGPAPKMLGNELCSVCGDKASGFHYNVLSCEGCKGFFRRSVIKGAHYICHSGGHCPMDTYMRRKCQECRLRKCRQAGMREECVLSEEQIRLKKLKRQEEEQAHATSLPPRASSPPQILPQLSPEQLGMIEKLVAAQQQCNRRSFSDRLRVTPWPMAPDPHSREARQQRFAHFTELAIVSVQEIVDFAKQLPGFLQLSREDQIALLKTSAIEVMLLETSRRYNPGSESITFLKDFSYNREDFAKAGLQVEFINPIFEFSRAMNELQLNDAEFALLIAISIFSADRPNVQDQLQVERLQHTYVEALHAYVSIHHPHDRLMFPRMLMKLVSLRTLSSVHSEQVFALRLQDKKLPPLLSEIWDVHE
  
Inhibitor
Name:
BDBM50415825
Synonyms:
CHEMBL1091034
Type:
Small organic molecule
Emp. Form.:
C27H23ClFNO4S2
Mol. Mass.:
544.057
SMILES:
CS(=O)(=O)c1cccc(c1)-c1ccc(CN(Cc2ccc(F)cc2Cl)S(=O)(=O)c2ccccc2)cc1
Structure:
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