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TargetBeta-3 adrenergic receptor
LigandBDBM25392
Substrate/Competitorn/a
Meas. Tech.ChEMBL_634435
EC50 40±n/a nM
Citation Procopiou, PABarrett, VJBevan, NJBiggadike, KBox, PCButchers, PRCoe, DMConroy, REmmons, AFord, AJHolmes, DSHorsley, HKerr, FLi-Kwai-Cheung, AMLooker, BEMann, ISMcLay, IMMorrison, VSMutch, PJSmith, CETomlin, P Synthesis and structure-activity relationships of long-acting beta2 adrenergic receptor agonists incorporating metabolic inactivation: an antedrug approach. J Med Chem53:4522-30 (2010) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Beta-3 adrenergic receptor
Name:Beta-2 adrenergic receptor and beta-3 adrenergic receptor
Synonyms:ADRB3 | B3AR | Beta-3 adrenoceptor | Beta-3 adrenoreceptor | adrenergic Beta3
Type:G Protein-Coupled Receptor (GPCR)
Mol. Mass.:43534.88
Organism:Homo sapiens (Human)
Description:n/a
Residue:408
Sequence:
MAPWPHENSSLAPWPDLPTLAPNTANTSGLPGVPWEAALAGALLALAVLATVGGNLLVIV
AIAWTPRLQTMTNVFVTSLAAADLVMGLLVVPPAATLALTGHWPLGATGCELWTSVDVLC
VTASIETLCALAVDRYLAVTNPLRYGALVTKRCARTAVVLVWVVSAAVSFAPIMSQWWRV
GADAEAQRCHSNPRCCAFASNMPYVLLSSSVSFYLPLLVMLFVYARVFVVATRQLRLLRG
ELGRFPPEESPPAPSRSLAPAPVGTCAPPEGVPACGRRPARLLPLREHRALCTLGLIMGT
FTLCWLPFFLANVLRALGGPSLVPGPAFLALNWLGYANSAFNPLIYCRSPDFRSAFRRLL
CRCGRRLPPEPCAAARPALFPSGVPAARSSPAQPRLCQRLDGASWGVS
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  Blast E-value cutoff:
BDBM25392
NameBDBM25392
Synonyms:4-[1-hydroxy-2-(isopropylamino)ethyl]pyrocatechol;hydrochloride | 4-[1-hydroxy-2-(propan-2-ylamino)ethyl]benzene-1,2-diol | 4-{1-hydroxy-2-[(propan-2-yl)amino]ethyl}benzene-1,2-diol, 2 | CHEMBL434 | ISOPROTERONOL | Isoprenaline | Isoproterenol | Isoproterenol (-) | Isoproterenol,(+) | Isoproterenol-l | Norisodrine | Novodrin
TypeSmall organic molecule
Emp. Form.C11H17NO3
Mol. Mass.211.2576
SMILESCC(C)NCC(O)c1ccc(O)c(O)c1
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least:
n/a