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TargetAlpha-2B adrenergic receptor
LigandBDBM50417349
Substrate/Competitorn/a
Meas. Tech.ChEMBL_684818
EC50 1000±n/a nM
Citation Del Bello, FMattioli, LGhelfi, FGiannella, MPiergentili, AQuaglia, WCardinaletti, CPerfumi, MThomas, RJZanelli, UMarchioro, CDal Cin, MPigini, M Fruitful adrenergica(2C)-agonism/a(2A)-antagonism combination to prevent and contrast morphine tolerance and dependence. J Med Chem53:7825-35 (2010) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Alpha-2B adrenergic receptor
Name:Alpha-2B adrenergic receptor
Synonyms:ADRA2B | ADRA2L1 | ADRA2L1 | ADRA2RL1 | Adrenergic alpha2B | Adrenergic receptor alpha | Adrenergic, alpha-2B-, receptor [Homo sapiens] | Alpha-2 adrenergic receptor subtype C2 | Alpha-2B adrenoceptor | Alpha-2B adrenoreceptor | Alpha-2BAR
Type:Enzyme
Mol. Mass.:49579.89
Organism:Homo sapiens (Human)
Description:P18089
Residue:450
Sequence:
MDHQDPYSVQATAAIAAAITFLILFTIFGNALVILAVLTSRSLRAPQNLFLVSLAAADIL
VATLIIPFSLANELLGYWYFRRTWCEVYLALDVLFCTSSIVHLCAISLDRYWAVSRALEY
NSKRTPRRIKCIILTVWLIAAVISLPPLIYKGDQGPQPRGRPQCKLNQEAWYILASSIGS
FFAPCLIMILVYLRIYLIAKRSNRRGPRAKGGPGQGESKQPRPDHGGALASAKLPALASV
ASAREVNGHSKSTGEKEEGETPEDTGTRALPPSWAALPNSGQGQKEGVCGASPEDEAEEE
EEEEEEEEECEPQAVPVSPASACSPPLQQPQGSRVLATLRGQVLLGRGVGAIGGQWWRRR
AQLTREKRFTFVLAVVIGVFVLCWFPFFFSYSLGAICPKHCKVPHGLFQFFFWIGYCNSS
LNPVIYTIFNQDFRRAFRRILCRPWTQTAW
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  Blast E-value cutoff:
BDBM50417349
NameBDBM50417349
Synonyms:CHEMBL1276248
TypeSmall organic molecule
Emp. Form.C15H16N2OS
Mol. Mass.272.365
SMILESC[C@H](Oc1ccccc1-c1ccsc1)C1=NCCN1 |r,t:16|
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least:
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