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TargetAlpha-2A adrenergic receptor
LigandBDBM50412250
Substrate/Competitorn/a
Meas. Tech.ChEMBL_684814
EC50 115±n/a nM
Citation Del Bello, FMattioli, LGhelfi, FGiannella, MPiergentili, AQuaglia, WCardinaletti, CPerfumi, MThomas, RJZanelli, UMarchioro, CDal Cin, MPigini, M Fruitful adrenergica(2C)-agonism/a(2A)-antagonism combination to prevent and contrast morphine tolerance and dependence. J Med Chem53:7825-35 (2010) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Alpha-2A adrenergic receptor
Name:Alpha-2A adrenergic receptor
Synonyms:Adrenergic alpha2A | Adrenergic receptor alpha | Alpha-2 adrenergic receptor subtype C10 | Alpha-2A adrenoceptor | Alpha-2A adrenoreceptor | Alpha-2AAR | alpha-2A adrenergic receptor [Homo sapiens]
Type:Enzyme
Mol. Mass.:48979.91
Organism:Homo sapiens (Human)
Description:P08913
Residue:450
Sequence:
MGSLQPDAGNASWNGTEAPGGGARATPYSLQVTLTLVCLAGLLMLLTVFGNVLVIIAVFT
SRALKAPQNLFLVSLASADILVATLVIPFSLANEVMGYWYFGKAWCEIYLALDVLFCTSS
IVHLCAISLDRYWSITQAIEYNLKRTPRRIKAIIITVWVISAVISFPPLISIEKKGGGGG
PQPAEPRCEINDQKWYVISSCIGSFFAPCLIMILVYVRIYQIAKRRTRVPPSRRGPDAVA
APPGGTERRPNGLGPERSAGPGGAEAEPLPTQLNGAPGEPAPAGPRDTDALDLEESSSSD
HAERPPGPRRPERGPRGKGKARASQVKPGDSLPRRGPGATGIGTPAAGPGEERVGAAKAS
RWRGRQNREKRFTFVLAVVIGVFVVCWFPFFFTYTLTAVGCSVPRTLFKFFFWFGYCNSS
LNPVIYTIFNHDFRRAFKKILCRGDRKRIV
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  Blast E-value cutoff:
BDBM50412250
n/a
NameBDBM50412250
Synonyms:CHEMBL128168
TypeSmall organic molecule
Emp. Form.C17H18N2O
Mol. Mass.266.3376
SMILESCC(Oc1ccccc1-c1ccccc1)C1=NCCN1 |t:17|
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least: