Target
Corticotropin-releasing factor receptor 1
Ligand
BDBM50417499
Substrate
n/a
Meas. Tech.
ChEMBL_685890
Ki
63.1±n/a nM
Citation
 Tellew, JELanier, MMoorjani, MLin, ELuo, ZSlee, DHZhang, XHoare, SRGrigoriadis, DESt Denis, YDi Fabio, RDi Modugno, ESaunders, JWilliams, JP Discovery of NBI-77860/GSK561679, a potent corticotropin-releasing factor (CRF1) receptor antagonist with improved pharmacokinetic properties. Bioorg Med Chem Lett 20:7259-64 (2010) [PubMed]  Article
Target
Name:
Corticotropin-releasing factor receptor 1
Synonyms:
CRF-R | CRF-R2 Alpha | CRF1 | CRH-R 1 | CRHR1 | Corticotropin releasing factor receptor 1 | Corticotropin-releasing factor receptor 1 (CRF-1) | Corticotropin-releasing factor receptor 1 (CRF1) | Corticotropin-releasing hormone receptor 1
Type:
Enzyme
Mol. Mass.:
50744.31
Organism:
Homo sapiens (Human)
Description:
P34998
Residue:
444
Sequence:
MGGHPQLRLVKALLLLGLNPVSASLQDQHCESLSLASNISGLQCNASVDLIGTCWPRSPAGQLVVRPCPAFFYGVRYNTTNNGYRECLANGSWAARVNYSECQEILNEEKKSKVHYHVAVIINYLGHCISLVALLVAFVLFLRLRPGCTHWGDQADGALEVGAPWSGAPFQVRRSIRCLRNIIHWNLISAFILRNATWFVVQLTMSPEVHQSNVGWCRLVTAAYNYFHVTNFFWMFGEGCYLHTAIVLTYSTDRLRKWMFICIGWGVPFPIIVAWAIGKLYYDNEKCWFGKRPGVYTDYIYQGPMILVLLINFIFLFNIVRILMTKLRASTTSETIQYRKAVKATLVLLPLLGITYMLFFVNPGEDEVSRVVFIYFNSFLESFQGFFVSVFYCFLNSEVRSAIRKRWHRWQDKHSIRARVARAMSIPTSPTRVSFHSIKQSTAV
  
Inhibitor
Name:
BDBM50417499
Synonyms:
CHEMBL1287848
Type:
Small organic molecule
Emp. Form.:
C20H22N6O2
Mol. Mass.:
378.4277
SMILES:
COc1ccc(-c2c(C)nn3c(NCc4nc(C)no4)cc(C)nc23)c(C)c1 |(6.38,-31.64,;4.84,-31.6,;4.1,-30.25,;2.56,-30.2,;1.84,-28.87,;2.63,-27.55,;1.89,-26.2,;2.79,-24.96,;4.33,-24.95,;1.88,-23.72,;.43,-24.19,;-.91,-23.43,;-.91,-21.89,;-2.31,-21.25,;-3.57,-22.14,;-5.03,-21.65,;-5.94,-22.86,;-7.48,-22.84,;-5.06,-24.13,;-3.58,-23.68,;-2.25,-24.2,;-2.24,-25.75,;-3.57,-26.52,;-.9,-26.5,;.43,-25.73,;4.17,-27.59,;4.97,-26.27,;4.91,-28.95,)|
Structure:
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