Target
Corticotropin-releasing factor receptor 1
Ligand
BDBM50417500
Substrate
n/a
Meas. Tech.
ChEMBL_685890
Ki
5.01±n/a nM
Citation
 Tellew, JELanier, MMoorjani, MLin, ELuo, ZSlee, DHZhang, XHoare, SRGrigoriadis, DESt Denis, YDi Fabio, RDi Modugno, ESaunders, JWilliams, JP Discovery of NBI-77860/GSK561679, a potent corticotropin-releasing factor (CRF1) receptor antagonist with improved pharmacokinetic properties. Bioorg Med Chem Lett 20:7259-64 (2010) [PubMed]  Article
Target
Name:
Corticotropin-releasing factor receptor 1
Synonyms:
CRF-R | CRF-R2 Alpha | CRF1 | CRH-R 1 | CRHR1 | Corticotropin releasing factor receptor 1 | Corticotropin-releasing factor receptor 1 (CRF-1) | Corticotropin-releasing factor receptor 1 (CRF1) | Corticotropin-releasing hormone receptor 1
Type:
Enzyme
Mol. Mass.:
50744.31
Organism:
Homo sapiens (Human)
Description:
P34998
Residue:
444
Sequence:
MGGHPQLRLVKALLLLGLNPVSASLQDQHCESLSLASNISGLQCNASVDLIGTCWPRSPAGQLVVRPCPAFFYGVRYNTTNNGYRECLANGSWAARVNYSECQEILNEEKKSKVHYHVAVIINYLGHCISLVALLVAFVLFLRLRPGCTHWGDQADGALEVGAPWSGAPFQVRRSIRCLRNIIHWNLISAFILRNATWFVVQLTMSPEVHQSNVGWCRLVTAAYNYFHVTNFFWMFGEGCYLHTAIVLTYSTDRLRKWMFICIGWGVPFPIIVAWAIGKLYYDNEKCWFGKRPGVYTDYIYQGPMILVLLINFIFLFNIVRILMTKLRASTTSETIQYRKAVKATLVLLPLLGITYMLFFVNPGEDEVSRVVFIYFNSFLESFQGFFVSVFYCFLNSEVRSAIRKRWHRWQDKHSIRARVARAMSIPTSPTRVSFHSIKQSTAV
  
Inhibitor
Name:
BDBM50417500
Synonyms:
CHEMBL1287877
Type:
Small organic molecule
Emp. Form.:
C22H26N6O2
Mol. Mass.:
406.4808
SMILES:
CCN(Cc1nc(C)no1)c1cc(C)nc2c(c(C)nn12)-c1ccc(OC)cc1C |(18.29,-22.05,;16.95,-21.3,;15.64,-22.08,;14.29,-21.33,;13.03,-22.21,;11.57,-21.7,;10.65,-22.92,;9.11,-22.88,;11.52,-24.19,;13,-23.75,;15.65,-23.62,;14.32,-24.41,;14.34,-25.95,;13.02,-26.74,;15.69,-26.7,;17.01,-25.91,;18.48,-26.37,;19.37,-25.12,;20.91,-25.1,;18.45,-23.89,;17,-24.38,;19.19,-27.74,;18.37,-29.04,;19.07,-30.39,;20.61,-30.47,;21.31,-31.83,;22.86,-31.91,;21.44,-29.18,;20.73,-27.81,;21.56,-26.51,)|
Structure:
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