Target
Corticotropin-releasing factor receptor 1
Ligand
BDBM50417510
Substrate
n/a
Meas. Tech.
ChEMBL_685890
Ki
50.12±n/a nM
Citation
 Tellew, JELanier, MMoorjani, MLin, ELuo, ZSlee, DHZhang, XHoare, SRGrigoriadis, DESt Denis, YDi Fabio, RDi Modugno, ESaunders, JWilliams, JP Discovery of NBI-77860/GSK561679, a potent corticotropin-releasing factor (CRF1) receptor antagonist with improved pharmacokinetic properties. Bioorg Med Chem Lett 20:7259-64 (2010) [PubMed]  Article
Target
Name:
Corticotropin-releasing factor receptor 1
Synonyms:
CRF-R | CRF-R2 Alpha | CRF1 | CRH-R 1 | CRHR1 | Corticotropin releasing factor receptor 1 | Corticotropin-releasing factor receptor 1 (CRF-1) | Corticotropin-releasing factor receptor 1 (CRF1) | Corticotropin-releasing hormone receptor 1
Type:
Enzyme
Mol. Mass.:
50744.31
Organism:
Homo sapiens (Human)
Description:
P34998
Residue:
444
Sequence:
MGGHPQLRLVKALLLLGLNPVSASLQDQHCESLSLASNISGLQCNASVDLIGTCWPRSPAGQLVVRPCPAFFYGVRYNTTNNGYRECLANGSWAARVNYSECQEILNEEKKSKVHYHVAVIINYLGHCISLVALLVAFVLFLRLRPGCTHWGDQADGALEVGAPWSGAPFQVRRSIRCLRNIIHWNLISAFILRNATWFVVQLTMSPEVHQSNVGWCRLVTAAYNYFHVTNFFWMFGEGCYLHTAIVLTYSTDRLRKWMFICIGWGVPFPIIVAWAIGKLYYDNEKCWFGKRPGVYTDYIYQGPMILVLLINFIFLFNIVRILMTKLRASTTSETIQYRKAVKATLVLLPLLGITYMLFFVNPGEDEVSRVVFIYFNSFLESFQGFFVSVFYCFLNSEVRSAIRKRWHRWQDKHSIRARVARAMSIPTSPTRVSFHSIKQSTAV
  
Inhibitor
Name:
BDBM50417510
Synonyms:
CHEMBL1288027
Type:
Small organic molecule
Emp. Form.:
C22H28N8O
Mol. Mass.:
420.5107
SMILES:
CCC(Nc1cc(C)nc2c(c(C)nn12)-c1cnc(cc1C)N(C)C)c1nc(C)no1 |(16.27,-27.55,;17.6,-28.32,;17.6,-29.86,;18.94,-30.63,;18.94,-32.17,;17.6,-32.95,;17.6,-34.5,;16.27,-35.27,;18.94,-35.26,;20.27,-34.5,;21.74,-34.98,;22.65,-33.73,;24.19,-33.73,;21.74,-32.48,;20.27,-32.95,;22.5,-36.33,;21.7,-37.64,;22.46,-38.99,;24,-39.01,;24.79,-37.67,;24.03,-36.33,;24.81,-35.01,;24.76,-40.35,;23.9,-41.64,;26.29,-40.45,;16.34,-30.74,;14.89,-30.24,;13.96,-31.46,;12.42,-31.42,;14.83,-32.73,;16.31,-32.29,)|
Structure:
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