Reaction Details Report a problem with these data
Target
Alpha-2C adrenergic receptor
Ligand
BDBM50196140
Substrate
n/a
Meas. Tech.
ChEMBL_735955 (CHEMBL1692251)
Ki
76.03±n/a nM
Citation
 Borota, A; Mracec, M; Gruia, A; Rad-Curpan, R; Ostopovici-Halip, L; Mracec, M A QSAR study using MTD method and Dragon descriptors for a series of selective ligands ofa2C adrenoceptor. Eur J Med Chem 46:877-84 (2011) [PubMed]  Article 
Target
Name:
Alpha-2C adrenergic receptor
Synonyms:
ADA2C_HUMAN | ADRA2C | ADRA2L2 | ADRA2RL2 | Adrenergic alpha2C | Adrenergic receptor | Adrenergic receptor alpha | Adrenergic, alpha-2C-, receptor | Alpha-2 adrenergic receptor subtype C4 | Alpha-2C adrenoceptor | Alpha-2C adrenoreceptor | adrenergic, alpha-2C-, receptor [Homo sapiens]
Type:
Enzyme
Mol. Mass.:
49552.32
Organism:
Homo sapiens (Human)
Description:
P18825
Residue:
462
Sequence:
MASPALAAALAVAAAAGPNASGAGERGSGGVANASGASWGPPRGQYSAGAVAGLAAVVGFLIVFTVVGNVLVVIAVLTSRALRAPQNLFLVSLASADILVATLVMPFSLANELMAYWYFGQVWCGVYLALDVLFCTSSIVHLCAISLDRYWSVTQAVEYNLKRTPRRVKATIVAVWLISAVISFPPLVSLYRQPDGAAYPQCGLNDETWYILSSCIGSFFAPCLIMGLVYARIYRVAKLRTRTLSEKRAPVGPDGASPTTENGLGAAAGAGENGHCAPPPADVEPDESSAAAERRRRRGALRRGGRRRAGAEGGAGGADGQGAGPGAAESGALTASRSPGPGGRLSRASSRSVEFFLSRRRRARSSVCRRKVAQAREKRFTFVLAVVMGVFVLCWFPFFFSYSLYGICREACQVPGPLFKFFFWIGYCNSSLNPVIYTVFNQDFRRSFKHILFRRRRRGFRQ
  
Inhibitor
Name:
BDBM50196140
Synonyms:
(S)-[4-(3,4-dimethylpiperazin-1-yl)phenyl]-(2,3,7-trimethylquinolin-4-yl)amine | CHEMBL217278
Type:
Small organic molecule
Emp. Form.:
C24H30N4
Mol. Mass.:
374.5218
SMILES:
C[C@H]1CN(CCN1C)c1ccc(Nc2c(C)c(C)nc3cc(C)ccc23)cc1
Structure:
Search PDB for entries with ligand similarity: