Reaction Details Report a problem with these data
Target
Cannabinoid receptor 2
Ligand
BDBM50419289
Substrate
n/a
Meas. Tech.
ChEMBL_772741 (CHEMBL1837353)
EC50
0.398±n/a nM
Citation
 van der Stelt, M; Cals, J; Broeders-Josten, S; Cottney, J; van der Doelen, AA; Hermkens, M; de Kimpe, V; King, A; Klomp, J; Oosterom, J; Pols-de Rooij, I; de Roos, J; van Tilborg, M; Boyce, S; Baker, J Discovery and optimization of 1-(4-(pyridin-2-yl)benzyl)imidazolidine-2,4-dione derivatives as a novel class of selective cannabinoid CB2 receptor agonists. J Med Chem 54:7350-62 (2011) [PubMed]  Article 
Target
Name:
Cannabinoid receptor 2
Synonyms:
CANNABINOID CB2 | CB-2 | CB2 | CB2A | CB2B | CNR2 | CNR2_HUMAN | CX5 | Cannabinoid CB2 receptor | Cannabinoid receptor 2 (CB2) | Cannabinoid receptor 2 (CB2R) | hCB2
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
39690.94
Organism:
Homo sapiens (Human)
Description:
P34972
Residue:
360
Sequence:
MEECWVTEIANGSKDGLDSNPMKDYMILSGPQKTAVAVLCTLLGLLSALENVAVLYLILSSHQLRRKPSYLFIGSLAGADFLASVVFACSFVNFHVFHGVDSKAVFLLKIGSVTMTFTASVGSLLLTAIDRYLCLRYPPSYKALLTRGRALVTLGIMWVLSALVSYLPLMGWTCCPRPCSELFPLIPNDYLLSWLLFIAFLFSGIIYTYGHVLWKAHQHVASLSGHQDRQVPGMARMRLDVRLAKTLGLVLAVLLICWFPVLALMAHSLATTLSDQVKKAFAFCSMLCLINSMVNPVIYALRSGEIRSSAHHCLAHWKKCVRGLGSEAKEEAPRSSVTETEADGKITPWPDSRDLDLSDC
  
Inhibitor
Name:
BDBM50419289
Synonyms:
CHEMBL1835215
Type:
Small organic molecule
Emp. Form.:
C25H30F2N4O2
Mol. Mass.:
456.5281
SMILES:
CC(C)Cn1c(O)cn(Cc2ccc(cc2)-c2ccc(F)c(CN3CCCC(F)C3)n2)c1=O
Structure:
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