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Target
Beta-1 adrenergic receptor
Ligand
BDBM50419650
Substrate
n/a
Meas. Tech.
ChEMBL_797651 (CHEMBL1943769)
EC50
251±n/a nM
Citation
 Jacobsen, JR; Choi, SK; Combs, J; Fournier, EJ; Klein, U; Pfeiffer, JW; Thomas, GR; Yu, C; Moran, EJ A multivalent approach to the discovery of long-actingß(2)-adrenoceptor agonists for the treatment of asthma and COPD. Bioorg Med Chem Lett 22:1213-8 (2012) [PubMed]  Article 
Target
Name:
Beta-1 adrenergic receptor
Synonyms:
ADRB1 | ADRB1R | ADRB1_HUMAN | B1AR | Beta-1 adrenoceptor | adrenergic Beta1
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
51338.40
Organism:
Homo sapiens (Human)
Description:
P08588
Residue:
477
Sequence:
MGAGVLVLGASEPGNLSSAAPLPDGAATAARLLVPASPPASLLPPASESPEPLSQQWTAGMGLLMALIVLLIVAGNVLVIVAIAKTPRLQTLTNLFIMSLASADLVMGLLVVPFGATIVVWGRWEYGSFFCELWTSVDVLCVTASIETLCVIALDRYLAITSPFRYQSLLTRARARGLVCTVWAISALVSFLPILMHWWRAESDEARRCYNDPKCCDFVTNRAYAIASSVVSFYVPLCIMAFVYLRVFREAQKQVKKIDSCERRFLGGPARPPSPSPSPVPAPAPPPGPPRPAAAAATAPLANGRAGKRRPSRLVALREQKALKTLGIIMGVFTLCWLPFFLANVVKAFHRELVPDRLFVFFNWLGYANSAFNPIIYCRSPDFRKAFQRLLCCARRAARRRHATHGDRPRASGCLARPGPPPSPGAASDDDDDDVVGATPPARLLEPWAGCNGGAAADSDSSLDEPCRPGFASESKV
  
Inhibitor
Name:
BDBM50419650
Synonyms:
CHEMBL1940830
Type:
Small organic molecule
Emp. Form.:
C25H30N2O4
Mol. Mass.:
422.5167
SMILES:
OCc1cc(ccc1O)[C@@H](O)CNCCc1ccc(NC[C@H](O)c2ccccc2)cc1 |r|
Structure:
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