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TargetAlpha adrenergic receptor (1a and 1d)
LigandBDBM50419700
Substrate/Competitorn/a
Meas. Tech.ChEMBL_800687
IC50 79±n/a nM
Citation Alcaraz, LBailey, ACadogan, EConnolly, SJewell, RJordan, SKindon, NLister, ALawson, MMullen, ADainty, INicholls, DPaine, SPairaudeau, GStocks, MJThorne, PYoung, A From libraries to candidate: the discovery of new ultra long-acting dibasicß2-adrenoceptor agonists. Bioorg Med Chem Lett22:689-95 (2011) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Alpha adrenergic receptor (1a and 1d)
Name:Adrenergic receptor alpha
Synonyms:Adrenergic receptor alpha | Alpha 1D-adrenoceptor | Alpha 1D-adrenoreceptor | Alpha-1D adrenergic receptor | Alpha-adrenergic receptor 1a | adrenergic Alpha1D
Type:Enzyme Catalytic Domain
Mol. Mass.:60485.82
Organism:HUMAN
Description:adrenergic Alpha1D ADRA1D HUMAN::P25100
Residue:572
Sequence:
MTFRDLLSVSFEGPRPDSSAGGSSAGGGGGSAGGAAPSEGPAVGGVPGGAGGGGGVVGAG
SGEDNRSSAGEPGSAGAGGDVNGTAAVGGLVVSAQGVGVGVFLAAFILMAVAGNLLVILS
VACNRHLQTVTNYFIVNLAVADLLLSATVLPFSATMEVLGFWAFGRAFCDVWAAVDVLCC
TASILSLCTISVDRYVGVRHSLKYPAIMTERKAAAILALLWVVALVVSVGPLLGWKEPVP
PDERFCGITEEAGYAVFSSVCSFYLPMAVIVVMYCRVYVVARSTTRSLEAGVKRERGKAS
EVVLRIHCRGAATGADGAHGMRSAKGHTFRSSLSVRLLKFSREKKAAKTLAIVVGVFVLC
WFPFFFVLPLGSLFPQLKPSEGVFKVIFWLGYFNSCVNPLIYPCSSREFKRAFLRLLRCQ
CRRRRRRRPLWRVYGHHWRASTSGLRQDCAPSSGDAPPGAPLALTALPDPDPEPPGTPEM
QAPVASRRKPPSAFREWRLLGPFRRPTTQLRAKVSSLSHKIRAGGAQRAEAACAQRSEVE
AVSLGVPHEVAEGATCQAYELADYSNLRETDI
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  Blast E-value cutoff:
BDBM50419700
n/a
NameBDBM50419700
Synonyms:CHEMBL1944689
TypeSmall organic molecule
Emp. Form.C26H27Cl2N3O3S
Mol. Mass.532.482
SMILESO[C@@H](CNCCc1ccc(CNCCc2c(Cl)cccc2Cl)cc1)c1ccc(O)c2[nH]c(=O)sc12 |r|
Structure
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