Reaction Details
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Alpha-2B adrenergic receptor
Ligand
BDBM50419883
Substrate
n/a
Meas. Tech.
ChEMBL_805962 (CHEMBL1960290)
EC50
316±n/a nM
Citation
Diamanti, E; Del Bello, F; Carbonara, G; Carrieri, A; Fracchiolla, G; Giannella, M; Mammoli, V; Piergentili, A; Pohjanoksa, K; Quaglia, W; Scheinin, M; Pigini, M Might the observeda(2A)-adrenoreceptor agonism or antagonism of allyphenyline analogues be ascribed to different molecular conformations? Bioorg Med Chem 20:2082-90 (2012) [PubMed] Article More Info.:
Target
Name:
Alpha-2B adrenergic receptor
Synonyms:
ADA2B_HUMAN | ADRA2B | ADRA2L1 | ADRA2RL1 | Adrenergic alpha2B | Adrenergic receptor | Adrenergic receptor alpha | Adrenergic, alpha-2B-, receptor [Homo sapiens] | Alpha-2 adrenergic receptor subtype C2 | Alpha-2B adrenoceptor | Alpha-2B adrenoreceptor | Alpha-2BAR
Type:
Enzyme
Mol. Mass.:
49964.20
Organism:
Homo sapiens (Human)
Description:
P18089
Residue:
450
Sequence:
MDHQDPYSVQATAAIAAAITFLILFTIFGNALVILAVLTSRSLRAPQNLFLVSLAAADILVATLIIPFSLANELLGYWYFRRTWCEVYLALDVLFCTSSIVHLCAISLDRYWAVSRALEYNSKRTPRRIKCIILTVWLIAAVISLPPLIYKGDQGPQPRGRPQCKLNQEAWYILASSIGSFFAPCLIMILVYLRIYLIAKRSNRRGPRAKGGPGQGESKQPRPDHGGALASAKLPALASVASAREVNGHSKSTGEKEEGETPEDTGTRALPPSWAALPNSGQGQKEGVCGASPEDEAEEEEEEEEEEEECEPQAVPVSPASACSPPLQQPQGSRVLATLRGQVLLGRGVGAIGGQWWRRRAQLTREKRFTFVLAVVIGVFVLCWFPFFFSYSLGAICPKHCKVPHGLFQFFFWIGYCNSSLNPVIYTIFNQDFRRAFRRILCRPWTQTAW
Inhibitor
Name:
BDBM50419883
Synonyms:
CHEMBL1956201
Type:
Small organic molecule
Emp. Form.:
C12H14N2O2
Mol. Mass.:
218.2518
SMILES:
CC(Oc1ccccc1C=O)C1=NCCN1 |t:12|
Structure:
