Reaction Details Report a problem with these data
Target
Solute carrier family 22 member 6
Ligand
BDBM25902
Substrate
n/a
Meas. Tech.
ChEMBL_838527 (CHEMBL2078155)
Ki
9500±n/a nM
Citation
 Uwai, Y; Saito, H; Hashimoto, Y; Inui, KI Interaction and transport of thiazide diuretics, loop diuretics, and acetazolamide via rat renal organic anion transporter rOAT1. J Pharmacol Exp Ther 295:261-5 (2000) [PubMed] 
Target
Name:
Solute carrier family 22 member 6
Synonyms:
Oat1 | Organic anion transporter 1 | S22A6_RAT | Slc22a6 | rOAT1 | rROAT1 | renal organic anion transporter 1
Type:
PROTEIN
Mol. Mass.:
60784.17
Organism:
Rattus norvegicus
Description:
ChEMBL_838479
Residue:
551
Sequence:
MAFNDLLKQVGGVGRFQLIQVTMVVAPLLLMASHNTLQNFTAAIPPHHCRPPANANLSKDGGLEAWLPLDKQGQPESCLRFTSPQWGPPFYNGTEANGTRVTEPCIDGWVYDNSTFPSTIVTEWNLVCSHRAFRQLAQSLYMVGVLLGAMVFGYLADRLGRRKVLILNYLQTAVSGTCAAYAPNYTVYCVFRLLSGMSLASIAINCMTLNVEWMPIHTRAYVGTLIGYVYSLGQFLLAGIAYAVPHWRHLQLVVSVPFFIAFIYSWFFIESARWYSSSGRLDLTLRALQRVARINGKQEEGAKLSIEVLRTSLQKELTLSKGQASAMELLRCPTLRHLFLCLSMLWFATSFAYYGLVMDLQGFGVSMYLIQVIFGAVDLPAKFVCFLVINSMGRRPAQMASLLLAGICILVNGIIPKSHTIIRTSLAVLGKGCLASSFNCIFLYTGELYPTVIRQTGLGMGSTMARVGSIVSPLVSMTAEFYPSMPLFIFGAVPVVASAVTALLPETLGQPLPDTVQDLKSRSRGKQNQQQQEQQKQMMPLQASTQEKNGL
  
Inhibitor
Name:
BDBM25902
Synonyms:
4-chloro-2-[(furan-2-ylmethyl)amino]-5-sulfamoylbenzoic acid | CHEMBL35 | Frusemide | Furanthril | Furosemide | Furosemide (3) | Furosemide, 4 | Lasix | US10172837, Furosemide
Type:
Small organic molecule
Emp. Form.:
C12H11ClN2O5S
Mol. Mass.:
330.744
SMILES:
NS(=O)(=O)c1cc(C(O)=O)c(NCc2ccco2)cc1Cl
Structure:
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