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Target
Alpha-1A adrenergic receptor
Ligand
BDBM50027060
Substrate
n/a
Meas. Tech.
ChEMBL_33755 (CHEMBL650229)
EC50
13±n/a nM
Citation
 Bishop, MJ; Barvian, KA; Berman, J; Bigham, EC; Garrison, DT; Gobel, MJ; Hodson, SJ; Irving, PE; Liacos, JA; Navas, F; Saussy, DL; Speake, JD alpha(1)-Adrenoceptor agonists: the identification of novel alpha(1A )subtype selective 2'-heteroaryl-2-(phenoxymethyl)imidazolines. Bioorg Med Chem Lett 12:471-5 (2002) [PubMed]  Article 
Target
Name:
Alpha-1A adrenergic receptor
Synonyms:
ADA1A_HUMAN | ADRA1A | ADRA1C | Adrenergic alpha1A | Alpha 1A-adrenoceptor | Alpha 1A-adrenoreceptor | Alpha adrenergic receptor 1a | Alpha-1C adrenergic receptor | Alpha-adrenergic receptor 1c | Cerebral cortex alpha adrenergic receptor | adrenergic Alpha1 | adrenergic Alpha1C
Type:
Cell-surface receptors
Mol. Mass.:
51511.67
Organism:
Homo sapiens (Human)
Description:
P35348
Residue:
466
Sequence:
MVFLSGNASDSSNCTQPPAPVNISKAILLGVILGGLILFGVLGNILVILSVACHRHLHSVTHYYIVNLAVADLLLTSTVLPFSAIFEVLGYWAFGRVFCNIWAAVDVLCCTASIMGLCIISIDRYIGVSYPLRYPTIVTQRRGLMALLCVWALSLVISIGPLFGWRQPAPEDETICQINEEPGYVLFSALGSFYLPLAIILVMYCRVYVVAKRESRGLKSGLKTDKSDSEQVTLRIHRKNAPAGGSGMASAKTKTHFSVRLLKFSREKKAAKTLGIVVGCFVLCWLPFFLVMPIGSFFPDFKPSETVFKIVFWLGYLNSCINPIIYPCSSQEFKKAFQNVLRIQCLCRKQSSKHALGYTLHPPSQAVEGQHKDMVRIPVGSRETFYRISKTDGVCEWKFFSSMPRGSARITVSKDQSSCTTARVRSKSFLQVCCCVGPSTPSLDKNHQVPTIKVHTISLSENGEEV
  
Inhibitor
Name:
BDBM50027060
Synonyms:
2-(2-Cyclopropyl-phenoxymethyl)-4,5-dihydro-1H-imidazole | 2-(2-Cyclopropyl-phenoxymethyl)-4,5-dihydro-1H-imidazole (cirazoline) | CHEMBL13852 | CIRAZOLINE
Type:
Small organic molecule
Emp. Form.:
C13H16N2O
Mol. Mass.:
216.2789
SMILES:
C(Oc1ccccc1C1CC1)C1=NCCN1 |t:13|
Structure:
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