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TargetDihydrofolate reductase
LigandBDBM50421786
Substrate/Competitorn/a
Meas. Tech.ChEMBL_55251
IC50 370±n/a nM
Citation Roth, BBaccanari, DPSigel, CWHubbell, JPEaddy, JKao, JCGrace, MERauckman, BS 2,4-Diamino-5-benzylpyrimidines and analogues as antibacterial agents. 9. Lipophilic trimethoprim analogues as antigonococcal agents. J Med Chem31:122-9 (1988) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Dihydrofolate reductase
Name:Dihydrofolate reductase
Synonyms:Dihydrofolate reductase (DHFR) | Tetrahydrofolate dehydrogenase
Type:Enzyme
Mol. Mass.:21453.99
Organism:Homo sapiens (Human)
Description:Recombinant human DHFR.
Residue:187
Sequence:
MVGSLNCIVAVSQNMGIGKNGDLPWPPLRNEFRYFQRMTTTSSVEGKQNLVIMGKKTWFS
IPEKNRPLKGRINLVLSRELKEPPQGAHFLSRSLDDALKLTEQPELANKVDMVWIVGGSS
VYKEAMNHPGHLKLFVTRIMQDFESDTFFPEIDLEKYKLLPEYPGVLSDVQEEKGIKYKF
EVYEKND
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BDBM50421786
NameBDBM50421786
Synonyms:CHEMBL287553
TypeSmall organic molecule
Emp. Form.C14H18N4O
Mol. Mass.258.3189
SMILESCOc1c(C)cc(Cc2cnc(N)nc2N)cc1C
Structure
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