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Target
Sigma non-opioid intracellular receptor 1
Ligand
BDBM50170657
Substrate
n/a
Meas. Tech.
ChEBML_201732
IC50
1.2±n/a nM
Citation
 Chambers, MS; Baker, R; Billington, DC; Knight, AK; Middlemiss, DN; Wong, EH Spiropiperidines as high-affinity, selective sigma ligands. J Med Chem 35:2033-9 (1992) [PubMed]  Article 
Target
Name:
Sigma non-opioid intracellular receptor 1
Synonyms:
Aging-associated gene 8 protein | OPRS1 | SGMR1_HUMAN | SIG-1R | SIGMAR1 | SR-BP | SR31747-binding protein | SRBP | Sigma 1-type opioid receptor | Sigma opioid receptor | Sigma1R | hSigmaR1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
25124.85
Organism:
Homo sapiens (Human)
Description:
Q99720
Residue:
223
Sequence:
MQWAVGRRWAWAALLLAVAAVLTQVVWLWLGTQSFVFQREEIAQLARQYAGLDHELAFSRLIVELRRLHPGHVLPDEELQWVFVNAGGWMGAMCLLHASLSEYVLLFGTALGSRGHSGRYWAEISDTIISGTFHQWREGTTKSEVFYPGETVVHGPGEATAVEWGPNTWMVEYGRGVIPSTLAFALADTVFSTQDFLTLFYTLRSYARGLRLELTTYLFGQDP
  
Inhibitor
Name:
BDBM50170657
Synonyms:
1''-butyl-3,4-dihydro-2H-spiro[naphthalene-1,4''-piperidine] | 1'-butyl-3,4-dihydro-2H-spiro[naphthalene-1,4'-piperidine]; HCl | CHEMBL1788381 | CHEMBL62540
Type:
Small organic molecule
Emp. Form.:
C18H27N
Mol. Mass.:
257.4137
SMILES:
CCCCN1CCC2(CCCc3ccccc23)CC1
Structure:
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