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Target
Melanin-concentrating hormone receptor 1
Ligand
BDBM50422911
Substrate
n/a
Meas. Tech.
ChEMBL_391803 (CHEMBL871566)
IC50
5.0±n/a nM
Citation
 Carpenter, AJ; Al-Barazanji, KA; Barvian, KK; Bishop, MJ; Britt, CS; Cooper, JP; Goetz, AS; Grizzle, MK; Hertzog, DL; Ignar, DM; Morgan, RO; Peckham, GE; Speake, JD; Swain, WR Novel benzimidazole-based MCH R1 antagonists. Bioorg Med Chem Lett 16:4994-5000 (2006) [PubMed]  Article 
Target
Name:
Melanin-concentrating hormone receptor 1
Synonyms:
G-protein coupled receptor 24 | GPR24 | MCH receptor 1 | MCH-1R | MCH-R1 | MCHR | MCHR-1 | MCHR1 | MCHR1_HUMAN | Melanin Concentrating Hormone 1 | Melanin-Concentrating Hormone Receptor 1 (MCH1R) | Melanin-concentrating hormone receptor | Melanin-concentrating hormone receptor 1 (MCH-1) | Melanin-concentrating hormone receptor 1 (MCH1) | Melanin-concentrating hormone receptor 1 (MCHR-1) | Melanin-concentrating hormone receptor 1 (MCHR1) | SLC-1 | SLC1 | Somatostatin receptor-like protein
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
45976.27
Organism:
Homo sapiens (Human)
Description:
Membranes from CHO-K1 cells stably expressing human MCH1R were used in assays.
Residue:
422
Sequence:
MSVGAMKKGVGRAVGLGGGSGCQATEEDPLPNCGACAPGQGGRRWRLPQPAWVEGSSARLWEQATGTGWMDLEASLLPTGPNASNTSDGPDNLTSAGSPPRTGSISYINIIMPSVFGTICLLGIIGNSTVIFAVVKKSKLHWCNNVPDIFIINLSVVDLLFLLGMPFMIHQLMGNGVWHFGETMCTLITAMDANSQFTSTYILTAMAIDRYLATVHPISSTKFRKPSVATLVICLLWALSFISITPVWLYARLIPFPGGAVGCGIRLPNPDTDLYWFTLYQFFLAFALPFVVITAAYVRILQRMTSSVAPASQRSIRLRTKRVTRTAIAICLVFFVCWAPYYVLQLTQLSISRPTLTFVYLYNAAISLGYANSCLNPFVYIVLCETFRKRLVLSVKPAAQGQLRAVSNAQTADEERTESKGT
  
Inhibitor
Name:
BDBM50422911
Synonyms:
CHEMBL387217
Type:
Small organic molecule
Emp. Form.:
C24H20ClN5OS
Mol. Mass.:
461.967
SMILES:
Clc1ccc(cc1)-c1cc2ncn(-c3ccc4nc([nH]c4c3)N3CCCCC3)c(=O)c2s1
Structure:
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