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Target
Tissue factor
Ligand
BDBM50424069
Substrate
n/a
Meas. Tech.
ChEMBL_936735 (CHEMBL2319887)
IC50
1501±n/a nM
Citation
 Ge, HX; Zhang, J; Chen, L; Kou, JP; Yu, BY Chemical and microbial semi-synthesis of tetrahydroprotoberberines as inhibitors on tissue factor procoagulant activity. Bioorg Med Chem 21:62-9 (2012) [PubMed]  Article 
Target
Name:
Tissue factor
Synonyms:
CD_antigen=CD142 | Coagulation factor III | Coagulation factor VII/tissue factor | F3 | TF | TF_HUMAN | Thromboplastin | Tissue factor
Type:
PROTEIN
Mol. Mass.:
33067.61
Organism:
Homo sapiens (Human)
Description:
ChEMBL_936735
Residue:
295
Sequence:
METPAWPRVPRPETAVARTLLLGWVFAQVAGASGTTNTVAAYNLTWKSTNFKTILEWEPKPVNQVYTVQISTKSGDWKSKCFYTTDTECDLTDEIVKDVKQTYLARVFSYPAGNVESTGSAGEPLYENSPEFTPYLETNLGQPTIQSFEQVGTKVNVTVEDERTLVRRNNTFLSLRDVFGKDLIYTLYYWKSSSSGKKTAKTNTNEFLIDVDKGENYCFSVQAVIPSRTVNRKSTDSPVECMGQEKGEFREIFYIIGAVVFVVIILVIILAISLHKCRKAGVGQSWKENSPLNVS
  
Inhibitor
Name:
BDBM50424069
Synonyms:
CHEMBL2314736
Type:
Small organic molecule
Emp. Form.:
C25H29NO5
Mol. Mass.:
423.5015
SMILES:
CCCCCC(=O)Oc1c(OC)ccc2CC3N(CCc4cc5OCOc5cc34)Cc12
Structure:
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