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Target
Acrosin
Ligand
BDBM50354886
Substrate
n/a
Meas. Tech.
ChEMBL_936791 (CHEMBL2320183)
IC50
142600000±n/a nM
Citation
 Chen, Q; Tian, W; Han, G; Qi, J; Zheng, C; Zhou, Y; Ding, L; Zhao, J; Zhu, J; Lv, J; Sheng, C Design and synthesis of novel benzoheterocyclic derivatives as human acrosin inhibitors by scaffold hopping. Eur J Med Chem 59:176-82 (2013) [PubMed]  Article 
Target
Name:
Acrosin
Synonyms:
ACR | ACRO_HUMAN | ACRS
Type:
PROTEIN
Mol. Mass.:
45865.48
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1365286
Residue:
421
Sequence:
MVEMLPTAILLVLAVSVVAKDNATCDGPCGLRFRQNPQGGVRIVGGKAAQHGAWPWMVSLQIFTYNSHRYHTCGGSLLNSRWVLTAAHCFVGKNNVHDWRLVFGAKEITYGNNKPVKAPLQERYVEKIIIHEKYNSATEGNDIALVEITPPISCGRFIGPGCLPHFKAGLPRGSQSCWVAGWGYIEEKAPRPSSILMEARVDLIDLDLCNSTQWYNGRVQPTNVCAGYPVGKIDTCQGDSGGPLMCKDSKESAYVVVGITSWGVGCARAKRPGIYTATWPYLNWIASKIGSNALRMIQSATPPPPTTRPPPIRPPFSHPISAHLPWYFQPPPRPLPPRPPAAQPRPPPSPPPPPPPPASPLPPPPPPPPPTPSSTTKLPQGLSFAKRLQQLIEVLKGKTYSDGKNHYDMETTELPELTSTS
  
Inhibitor
Name:
BDBM50354886
Synonyms:
CHEMBL466465
Type:
Small organic molecule
Emp. Form.:
C14H21ClN2O3S
Mol. Mass.:
332.846
SMILES:
Cc1ccc(cc1)S(=O)(=O)N[C@@H](CCCCN)C(=O)CCl |r|
Structure:
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