Reaction Details Report a problem with these data
Target
Galectin-1
Ligand
BDBM50077225
Substrate
n/a
Meas. Tech.
ChEMBL_936060 (CHEMBL2319302)
Kd
24000±n/a nM
Citation
 van Hattum, H; Branderhorst, HM; Moret, EE; Nilsson, UJ; Leffler, H; Pieters, RJ Tuning the preference of thiodigalactoside- and lactosamine-based ligands to galectin-3 over galectin-1. J Med Chem 56:1350-4 (2013) [PubMed]  Article 
Target
Name:
Galectin-1
Synonyms:
14 kDa lectin | Galaptin | HPL | LEG1_HUMAN | LGALS1 | Lactose-binding lectin 1 | Lectin galactoside-binding soluble 1 | Putative MAPK-activating protein PM12
Type:
beta galactoside-binding protein
Mol. Mass.:
14713.53
Organism:
Homo sapiens (Human)
Description:
P09382
Residue:
135
Sequence:
MACGLVASNLNLKPGECLRVRGEVAPDAKSFVLNLGKDSNNLCLHFNPRFNAHGDANTIVCNSKDGGAWGTEQREAVFPFQPGSVAEVCITFDQANLTVKLPDGYEFKFPNRLNLEAINYMAADGDFKIKCVAFD
  
Inhibitor
Name:
BDBM50077225
Synonyms:
(2R,3R,4S,5R,6S)-2-(hydroxymethyl)-6-{[(2S,3R,4S,5R,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl]thio}tetrahydro-2H-pyran-3,4,5-triol | CHEMBL52011 | THIODIGALACTOSIDE
Type:
Small organic molecule
Emp. Form.:
C12H22O10S
Mol. Mass.:
358.362
SMILES:
OC[C@H]1O[C@@H](S[C@@H]2O[C@H](CO)[C@H](O)[C@H](O)[C@H]2O)[C@H](O)[C@@H](O)[C@H]1O |r|
Structure:
Search PDB for entries with ligand similarity: