Reaction Details Report a problem with these data
Target
Casein kinase I isoform alpha
Ligand
BDBM7401
Substrate
n/a
Meas. Tech.
ChEMBL_939731 (CHEMBL2329084)
IC50
1200±n/a nM
Citation
Myrianthopoulos, V; Kritsanida, M; Gaboriaud-Kolar, N; Magiatis, P; Ferandin, Y; Durieu, E; Lozach, O; Cappel, D; Soundararajan, M; Filippakopoulos, P; Sherman, W; Knapp, S; Meijer, L; Mikros, E; Skaltsounis, AL Novel Inverse Binding Mode of Indirubin Derivatives Yields Improved Selectivity for DYRK Kinases. ACS Med Chem Lett 4:22-26 (2013) [PubMed] Article
More Info.:
Target
Name:
Casein kinase I isoform alpha
Synonyms:
CK1 | CKI-alpha | CSNK1A1 | KC1A_PIG
Type:
PROTEIN
Mol. Mass.:
14639.55
Organism:
Sus scrofa
Description:
ChEMBL_939731
Residue:
125
Sequence:
GEEVAVKLESQKARHPQLLYESKLYKILQGGVGIPHIRWYGQEKDYNVLVMDLLGPSLEDLFNFCSRRFTMKTVLMLADQMISRIEYVHTKNFIHRDIKPDNFLMGIGRHCNKLFLIDFGLAKKY
Inhibitor
Name:
BDBM7401
Synonyms:
(2 Z,3 E)-6-Bromoindirubin-3 -oxime | (3E)-6-bromo-3-[3-(hydroxyamino)indol-2-ylidene]oxindole | 6-bromo-3-[(2Z,3E)-3-(hydroxyimino)-2,3-dihydro-1H-indol-2-ylidene]-2,3-dihydro-1H-indol-2-one | 6-bromoindirubin-3 -oxime | 6BIO | CHEMBL409450 | indirubin deriv. 7a
Type:
Small organic molecule
Emp. Form.:
C16H10BrN3O2
Mol. Mass.:
356.174
SMILES:
Brc1ccc2C(C(=O)Nc2c1)c1[nH]c2ccccc2c1N=O