| Reaction Details |
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 | Report a problem with these data |
| Target | NEDD8-activating enzyme E1 regulatory subunit |
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| Ligand | BDBM50427031 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_939689 |
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| IC50 | 800±n/a nM |
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| Citation |  da Silva, SR; Paiva, SL; Lukkarila, JL; Gunning, PT Exploring a new frontier in cancer treatment: targeting the ubiquitin and ubiquitin-like activating enzymes. J Med Chem56:2165-77 (2013) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| NEDD8-activating enzyme E1 regulatory subunit |
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| Name: | NEDD8-activating enzyme E1 regulatory subunit |
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| Synonyms: | APP-BP1 | APPBP1 | Amyloid beta precursor protein-binding protein 1, 59 kDa | Amyloid protein-binding protein 1 | NAE1 | Proto-oncogene protein 1 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 60233.54 |
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| Organism: | Homo sapiens |
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| Description: | ChEMBL_939705 |
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| Residue: | 534 |
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| Sequence: | MAQLGKLLKEQKYDRQLRLWGDHGQEALESAHVCLINATATGTEILKNLVLPGIGSFTII
DGNQVSGEDAGNNFFLQRSSIGKNRAEAAMEFLQELNSDVSGSFVEESPENLLDNDPSFF
CRFTVVVATQLPESTSLRLADVLWNSQIPLLICRTYGLVGYMRIIIKEHPVIESHPDNAL
EDLRLDKPFPELREHFQSYDLDHMEKKDHSHTPWIVIIAKYLAQWYSETNGRIPKTYKEK
EDFRDLIRQGILKNENGAPEDEENFEEAIKNVNTALNTTQIPSSIEDIFNDDRCINITKQ
TPSFWILARALKEFVAKEGQGNLPVRGTIPDMIADSGKYIKLQNVYREKAKKDAAAVGNH
VAKLLQSIGQAPESISEKELKLLCSNSAFLRVVRCRSLAEEYGLDTINKDEIISSMDNPD
NEIVLYLMLRAVDRFHKQQGRYPGVSNYQVEEDIGKLKSCLTGFLQEYGLSVMVKDDYVH
EFCRYGAAEPHTIAAFLGGAAAQEVIKIITKQFVIFNNTYIYSGMSQTSATFQL
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| BDBM50427031 |
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| Name | BDBM50427031 |
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| Synonyms: | CHEMBL2322197 |
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| Type | Small organic molecule |
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| Emp. Form. | C17H18N4O6 |
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| Mol. Mass. | 374.348 |
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| SMILES | OC(=O)CNC(=O)CNC(=O)COc1ccc2nc3CCCn3c(=O)c2c1 |
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| Structure | 
|
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| n/a |
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