Reaction Details |
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Target | NEDD8-activating enzyme E1 regulatory subunit |
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Ligand | BDBM50427031 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_939689 |
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IC50 | 800±n/a nM |
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Citation | da Silva, SR; Paiva, SL; Lukkarila, JL; Gunning, PT Exploring a new frontier in cancer treatment: targeting the ubiquitin and ubiquitin-like activating enzymes. J Med Chem56:2165-77 (2013) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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NEDD8-activating enzyme E1 regulatory subunit |
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Name: | NEDD8-activating enzyme E1 regulatory subunit |
Synonyms: | APP-BP1 | APPBP1 | Amyloid beta precursor protein-binding protein 1, 59 kDa | Amyloid protein-binding protein 1 | NAE1 | Proto-oncogene protein 1 |
Type: | PROTEIN |
Mol. Mass.: | 60233.54 |
Organism: | Homo sapiens |
Description: | ChEMBL_939705 |
Residue: | 534 |
Sequence: | MAQLGKLLKEQKYDRQLRLWGDHGQEALESAHVCLINATATGTEILKNLVLPGIGSFTII
DGNQVSGEDAGNNFFLQRSSIGKNRAEAAMEFLQELNSDVSGSFVEESPENLLDNDPSFF
CRFTVVVATQLPESTSLRLADVLWNSQIPLLICRTYGLVGYMRIIIKEHPVIESHPDNAL
EDLRLDKPFPELREHFQSYDLDHMEKKDHSHTPWIVIIAKYLAQWYSETNGRIPKTYKEK
EDFRDLIRQGILKNENGAPEDEENFEEAIKNVNTALNTTQIPSSIEDIFNDDRCINITKQ
TPSFWILARALKEFVAKEGQGNLPVRGTIPDMIADSGKYIKLQNVYREKAKKDAAAVGNH
VAKLLQSIGQAPESISEKELKLLCSNSAFLRVVRCRSLAEEYGLDTINKDEIISSMDNPD
NEIVLYLMLRAVDRFHKQQGRYPGVSNYQVEEDIGKLKSCLTGFLQEYGLSVMVKDDYVH
EFCRYGAAEPHTIAAFLGGAAAQEVIKIITKQFVIFNNTYIYSGMSQTSATFQL
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BDBM50427031 |
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Name | BDBM50427031 |
Synonyms: | CHEMBL2322197 |
Type | Small organic molecule |
Emp. Form. | C17H18N4O6 |
Mol. Mass. | 374.348 |
SMILES | OC(=O)CNC(=O)CNC(=O)COc1ccc2nc3CCCn3c(=O)c2c1 |
Structure |
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n/a |
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