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Target
Renin
Ligand
BDBM50427041
Substrate
n/a
Meas. Tech.
ChEMBL_939878 (CHEMBL2329603)
Kd
>500000±n/a nM
Citation
 Ostermann, N; Ruedisser, S; Ehrhardt, C; Breitenstein, W; Marzinzik, A; Jacoby, E; Vangrevelinghe, E; Ottl, J; Klumpp, M; Hartwieg, JC; Cumin, F; Hassiepen, U; Trappe, J; Sedrani, R; Geisse, S; Gerhartz, B; Richert, P; Francotte, E; Wagner, T; Krömer, M; Kosaka, T; Webb, RL; Rigel, DF; Maibaum, J; Baeschlin, DK A novel class of oral direct renin inhibitors: highly potent 3,5-disubstituted piperidines bearing a tricyclic p3-p1 pharmacophore. J Med Chem 56:2196-206 (2013) [PubMed]  Article 
Target
Name:
Renin
Synonyms:
Angiotensinogenase | REN | RENI_HUMAN
Type:
Enzyme
Mol. Mass.:
45058.99
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
406
Sequence:
MDGWRRMPRWGLLLLLWGSCTFGLPTDTTTFKRIFLKRMPSIRESLKERGVDMARLGPEWSQPMKRLTLGNTTSSVILTNYMDTQYYGEIGIGTPPQTFKVVFDTGSSNVWVPSSKCSRLYTACVYHKLFDASDSSSYKHNGTELTLRYSTGTVSGFLSQDIITVGGITVTQMFGEVTEMPALPFMLAEFDGVVGMGFIEQAIGRVTPIFDNIISQGVLKEDVFSFYYNRDSENSQSLGGQIVLGGSDPQHYEGNFHYINLIKTGVWQIQMKGVSVGSSTLLCEDGCLALVDTGASYISGSTSSIEKLMEALGAKKRLFDYVVKCNEGPTLPDISFHLGGKEYTLTSADYVFQESYSSKKLCTLAIHAMDIPPPTGPTWALGATFIRKFYTEFDRRNNRIGFALAR
  
Inhibitor
Name:
BDBM50427041
Synonyms:
CHEMBL2322210
Type:
Small organic molecule
Emp. Form.:
C19H22N2O
Mol. Mass.:
294.3908
SMILES:
CC(O)CN1CC2C(C1)c1ccccc1Nc1ccccc21
Structure:
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