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Target
Protein-serine O-palmitoleoyltransferase porcupine
Ligand
BDBM50428033
Substrate
n/a
Meas. Tech.
ChEMBL_941167 (CHEMBL2330993)
EC50
30±n/a nM
Citation
 Wang, X; Moon, J; Dodge, ME; Pan, X; Zhang, L; Hanson, JM; Tuladhar, R; Ma, Z; Shi, H; Williams, NS; Amatruda, JF; Carroll, TJ; Lum, L; Chen, C The development of highly potent inhibitors for porcupine. J Med Chem 56:2700-4 (2013) [PubMed]  Article 
Target
Name:
Protein-serine O-palmitoleoyltransferase porcupine
Synonyms:
PORCN_MOUSE | Porc | Porcn | Ppn | Probable protein-cysteine N-palmitoyltransferase porcupine | Protein-cysteine N-palmitoyltransferase porcupine | mPORC
Type:
PROTEIN
Mol. Mass.:
52528.36
Organism:
Mus musculus
Description:
ChEMBL_941167
Residue:
461
Sequence:
MATFSRQEFFQQLLQGCLLPTVQQGLDQIWLLLTICFACRLLWRLGLPSYLKHASTVAGGFFSLYHFFQLHMVWVVLLSLLCYLVLFLCRHSSHRGVFLSVTILIYLLMGEMHMVDTVTWHKMRGAQMIVAMKAVSLGFDLDRGEVGAVPSPVEFMGYLYFVGTIVFGPWISFHSYLQAVQGRPLSRRWLKKVARSLALALLCLVLSTCVGPYLFPYFIPLDGDRLLRNKKRKARGTMVRWLRAYESAVSFHFSNYFVGFLSEATATLAGAGFTEEKDHLEWDLTVSRPLNVELPRSMVEVVTSWNLPMSYWLNNYVFKNALRLGTFSAVLVTYAASALLHGFSFHLAAVLLSLAFITYVEHVLRKRLAQILSACILSKRCLPDCSHRHRLGLGVRALNLLFGALAIFHLSYLGSLFDVDVDDTTEEQGYGMAYTVHKWSELSWASHWVTFGCWIFYRLIG
  
Inhibitor
Name:
BDBM50428033
Synonyms:
CHEMBL2325505
Type:
Small organic molecule
Emp. Form.:
C23H17F3N4O3S3
Mol. Mass.:
550.596
SMILES:
COc1ccccc1-n1c(SCC(=O)Nc2nc3ccc(cc3s2)C(F)(F)F)nc2CCSc2c1=O |(46.71,-19.26,;45.38,-20.03,;45.39,-21.58,;46.72,-22.34,;46.73,-23.89,;45.4,-24.66,;44.06,-23.89,;44.06,-22.35,;42.73,-21.58,;42.73,-20.03,;44.06,-19.25,;44.05,-17.71,;45.39,-16.94,;45.38,-15.4,;46.72,-17.7,;48.05,-16.93,;49.46,-17.55,;50.48,-16.4,;52.02,-16.4,;52.78,-15.06,;52,-13.73,;50.47,-13.74,;49.71,-15.07,;48.2,-15.39,;52.76,-12.39,;54.3,-12.38,;51.98,-11.06,;53.52,-11.05,;41.39,-19.26,;40.05,-20.04,;38.59,-19.57,;37.69,-20.82,;38.6,-22.06,;40.06,-21.58,;41.39,-22.35,;41.39,-23.89,)|
Structure:
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