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Target
Vascular endothelial growth factor receptor 2
Ligand
BDBM50429506
Substrate
n/a
Meas. Tech.
ChEMBL_943682 (CHEMBL2344826)
IC50
>100000±n/a nM
Citation
 Yang, LL; Li, GB; Ma, S; Zou, C; Zhou, S; Sun, QZ; Cheng, C; Chen, X; Wang, LJ; Feng, S; Li, LL; Yang, SY Structure-activity relationship studies of pyrazolo[3,4-d]pyrimidine derivatives leading to the discovery of a novel multikinase inhibitor that potently inhibits FLT3 and VEGFR2 and evaluation of its activity against acute myeloid leukemia in vitro and in vivo. J Med Chem 56:1641-55 (2013) [PubMed]  Article 
Target
Name:
Vascular endothelial growth factor receptor 2
Synonyms:
FLK-1b | Fetal liver kinase 1b | Kinase insert domain receptor | Kinase insert domain receptor-B | Protein-tyrosine kinase receptor flk-1b | VEGFR-2 | VEGFR-2 homolog B | VGFR2_DANRE | Vascular endothelial growth factor receptor 2 homolog B | flk1b | kdr | kdrb | si:ch211-254j6.1
Type:
PROTEIN
Mol. Mass.:
153046.15
Organism:
Danio rerio
Description:
ChEMBL_943682
Residue:
1357
Sequence:
MAKTSYALLLLDILLTFNVAKAIELRFVPDPPTLNITEKTIKINASDTLQITCRGRQILEWSTPHNRTSSETRLTISDCSGDGLFCSTLTLSKAVANETGEYRCFYKSLPKEDGKTSVAVYVFIQDYRTPFVRIAQDYDVVFIREGEQVVIPCLVSVEDLNVTLYTKYPVKELSTDGKEVIWDSRRGFILPSRVVSYAGVVYCQTTIRNETFQSSPYIVAVVGYKIYDLTLSPQHERLTVGERLILNCTAHTELNVGIDFQWTFPHEKRSVNGSMSTSRYKTSSNKKKLWNSLELSNTLTVENVTLNDTGEYICTASSGQMQKIAQASLIVYEKPFIALSDQLWQTVEAKAGDAEAKILVKYYAYPEPAVRWYKNDQLIVLRDEYRMKFYRGVHLTIYGVTEKDAGNYTVVMTNKITKEEQRRTFQLVVNDLPRIFEKDVSLDRDVHMYGSSPTLTCTASGGSSPVTIKWQWMPREDCPVRFLPKSDTRMAKCDKWREMSNNTGKNPLISQTSVDERTLKTISTLKIQKAVDHALYRCIATNKMGQDQRVIVFQVTRFLNLSVLPSSSPIEGQDVIMRCVADRLLYYNLRWYRVANVANHDPPPAAVPCDTLTLSHLHQPNVTVSGLQGTNVTLDMPIPNATMMDQGLYACQVEIVGTNEKTCLLHNLRLRALEMSRIVTNLTDQRVNVSDSTTLVCEVSGTPTPTIVWTKDNQTVMEGSGVILKRSNRVLTIQRVKKEDSGLYICTACNQQGCESSEARISVDGAEEKMNVELIMPIGAVVIAMFLWLLIVFVIRNRKRPNDGDLKTGYLSIILDSDDMPMDEHCERLTYDASKWEFPRDRLKLGEPLGRGAFGQVVEATAYGIEKATTCTTVAVKMLKEGATSSEYRALMSELKILIHIGHHLNVVNLLGACTKQGGPLMVIVEYCKHGNLSSYLKSKRGEYSPYKKRTPRMPNRREVQQDEDPREGDLGLGTSTRLDICTGTAVCTRTGEQTYKTLQDEQESSDWDHLTMEDLISYSFQVAKGMEFLASRKCIHRDLAARNILLSENSVVKICDFGLARDVYKDPDYVRKGDARLPLKWMAPETIFDRVYTTQSDVWSFGVLLWEIFSLGASPYPGVCIDESFCRRLKEGTRMRAPDYATPEIYQTMLDCWLDRPLDRPTFTQLVEHLGNLLQASAQQDGKDYIPLTNGEMEEELVAPHLNVTSKRSFYAGNTEAQLHYDNAPPLGFPQQMNSSGVPVNMTGFVDIPLEHTTVMDGHVDCGVGLSREQMKALDRQAQRPLNFSPLLRCKSKESLASESSNQTSGYQSGYHSDDAEAPIYANEEMILKRDIRKKPPLPKRNDKFSAEVRYSAPPV
  
Inhibitor
Name:
BDBM50429506
Synonyms:
CHEMBL2332844
Type:
Small organic molecule
Emp. Form.:
C19H14F3N7O
Mol. Mass.:
413.356
SMILES:
FC(F)(F)c1ccc(NC(=O)Nc2ccc(Nc3ncnc4n[nH]cc34)cc2)cc1
Structure:
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