Reaction Details Report a problem with these data
Target
Histone deacetylase 2
Ligand
BDBM50429526
Substrate
n/a
Meas. Tech.
ChEMBL_944722 (CHEMBL2340968)
Temperature
298.15±n/a K
IC50
>33330±n/a nM
Comments
extracted
Citation
 Wagner, FF; Olson, DE; Gale, JP; Kaya, T; Weïwer, M; Aidoud, N; Thomas, M; Davoine, EL; Lemercier, BC; Zhang, YL; Holson, EB Potent and selective inhibition of histone deacetylase 6 (HDAC6) does not require a surface-binding motif. J Med Chem 56:1772-6 (2013) [PubMed]  Article 
Target
Name:
Histone deacetylase 2
Synonyms:
Cereblon/Histone deacetylase 2 | HD2 | HDAC2 | HDAC2_HUMAN | Histone deacetylase 2 (HDAC2) | Human HDAC2
Type:
Chromatin regulator; hydrolase; repressor
Mol. Mass.:
55356.54
Organism:
Homo sapiens (Human)
Description:
Q92769
Residue:
488
Sequence:
MAYSQGGGKKKVCYYYDGDIGNYYYGQGHPMKPHRIRMTHNLLLNYGLYRKMEIYRPHKATAEEMTKYHSDEYIKFLRSIRPDNMSEYSKQMQRFNVGEDCPVFDGLFEFCQLSTGGSVAGAVKLNRQQTDMAVNWAGGLHHAKKSEASGFCYVNDIVLAILELLKYHQRVLYIDIDIHHGDGVEEAFYTTDRVMTVSFHKYGEYFPGTGDLRDIGAGKGKYYAVNFPMRDGIDDESYGQIFKPIISKVMEMYQPSAVVLQCGADSLSGDRLGCFNLTVKGHAKCVEVVKTFNLPLLMLGGGGYTIRNVARCWTYETAVALDCEIPNELPYNDYFEYFGPDFKLHISPSNMTNQNTPEYMEKIKQRLFENLRMLPHAPGVQMQAIPEDAVHEDSGDEDGEDPDKRISIRASDKRIACDEEFSDSEDEGEGGRRNVADHKKGAKKARIEEDKKETEDKKTDVKEEDKSKDNSGEKTDTKGTKSEQLSNP
  
Inhibitor
Name:
BDBM50429526
Synonyms:
CHEMBL2333345 | N-Hydroxycyclohexanecarboxamide
Type:
Small organic molecule
Emp. Form.:
C7H13NO2
Mol. Mass.:
143.1836
SMILES:
ONC(=O)C1CCCCC1
Structure:
Search PDB for entries with ligand similarity: