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TargetAminopeptidase N
LigandBDBM50430636
Substrate/Competitorn/a
Meas. Tech.ChEMBL_942089
IC50 1310±n/a nM
Citation Ma, CJin, KCao, JZhang, LLi, XXu, W Novel leucine ureido derivatives as inhibitors of aminopeptidase N (APN). Bioorg Med Chem21:1621-7 (2013) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Aminopeptidase N
Name:Aminopeptidase
Synonyms:Alanyl aminopeptidase | CD_antigen=CD13 | Microsomal aminopeptidase | Myeloid plasma membrane glycoprotein CD13 | gp150 | hAPN
Type:PROTEIN
Mol. Mass.:109522.63
Organism:Homo sapiens (Human)
Description:ChEMBL_1507526
Residue:967
Sequence:
MAKGFYISKSLGILGILLGVAAVCTIIALSVVYSQEKNKNANSSPVASTTPSASATTNPA
SATTLDQSKAWNRYRLPNTLKPDSYRVTLRPYLTPNDRGLYVFKGSSTVRFTCKEATDVI
IIHSKKLNYTLSQGHRVVLRGVGGSQPPDIDKTELVEPTEYLVVHLKGSLVKDSQYEMDS
EFEGELADDLAGFYRSEYMEGNVRKVVATTQMQAADARKSFPCFDEPAMKAEFNITLIHP
KDLTALSNMLPKGPSTPLPEDPNWNVTEFHTTPKMSTYLLAFIVSEFDYVEKQASNGVLI
RIWARPSAIAAGHGDYALNVTGPILNFFAGHYDTPYPLPKSDQIGLPDFNAGAMENWGLV
TYRENSLLFDPLSSSSSNKERVVTVIAHELAHQWFGNLVTIEWWNDLWLNEGFASYVEYL
GADYAEPTWNLKDLMVLNDVYRVMAVDALASSHPLSTPASEINTPAQISELFDAISYSKG
ASVLRMLSSFLSEDVFKQGLASYLHTFAYQNTIYLNLWDHLQEAVNNRSIQLPTTVRDIM
NRWTLQMGFPVITVDTSTGTLSQEHFLLDPDSNVTRPSEFNYVWIVPITSIRDGRQQQDY
WLIDVRAQNDLFSTSGNEWVLLNLNVTGYYRVNYDEENWRKIQTQLQRDHSAIPVINRAQ
IINDAFNLASAHKVPVTLALNNTLFLIEERQYMPWEAALSSLSYFKLMFDRSEVYGPMKN
YLKKQVTPLFIHFRNNTNNWREIPENLMDQYSEVNAISTACSNGVPECEEMVSGLFKQWM
ENPNNNPIHPNLRSTVYCNAIAQGGEEEWDFAWEQFRNATLVNEADKLRAALACSKELWI
LNRYLSYTLNPDLIRKQDATSTIISITNNVIGQGLVWDFVQSNWKKLFNDYGGGSFSFSN
LIQAVTRRFSTEYELQQLEQFKKDNEETGFGSGTRALEQALEKTKANIKWVKENKEVVLQ
WFTENSK
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50430636
NameBDBM50430636
Synonyms:CHEMBL2332524
TypeSmall organic molecule
Emp. Form.C13H18ClN3O3
Mol. Mass.299.753
SMILESCC(C)C[C@H](NC(=O)Nc1ccccc1Cl)C(=O)NO |r|
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least:
n/a