| Reaction Details |
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 | Report a problem with these data |
| Target | Alpha-ketoglutarate-dependent dioxygenase FTO |
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| Ligand | BDBM50277936 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_947323 |
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| IC50 | 60000±n/a nM |
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| Citation |  Aik, W; Demetriades, M; Hamdan, MK; Bagg, EA; Yeoh, KK; Lejeune, C; Zhang, Z; McDonough, MA; Schofield, CJ Structural basis for inhibition of the fat mass and obesity associated protein (FTO). J Med Chem56:3680-8 (2013) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Alpha-ketoglutarate-dependent dioxygenase FTO |
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| Name: | Alpha-ketoglutarate-dependent dioxygenase FTO |
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| Synonyms: | FTO | Fat mass and obesity-associated protein | KIAA1752 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 58263.75 |
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| Organism: | Homo sapiens |
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| Description: | ChEMBL_1515854 |
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| Residue: | 505 |
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| Sequence: | MKRTPTAEEREREAKKLRLLEELEDTWLPYLTPKDDEFYQQWQLKYPKLILREASSVSEE
LHKEVQEAFLTLHKHGCLFRDLVRIQGKDLLTPVSRILIGNPGCTYKYLNTRLFTVPWPV
KGSNIKHTEAEIAAACETFLKLNDYLQIETIQALEELAAKEKANEDAVPLCMSADFPRVG
MGSSYNGQDEVDIKSRAAYNVTLLNFMDPQKMPYLKEEPYFGMGKMAVSWHHDENLVDRS
AVAVYSYSCEGPEEESEDDSHLEGRDPDIWHVGFKISWDIETPGLAIPLHQGDCYFMLDD
LNATHQHCVLAGSQPRFSSTHRVAECSTGTLDYILQRCQLALQNVCDDVDNDDVSLKSFE
PAVLKQGEEIHNEVEFEWLRQFWFQGNRYRKCTDWWCQPMAQLEALWKKMEGVTNAVLHE
VKREGLPVEQRNEILTAILASLTARQNLRREWHARCQSRIARTLPADQKPECRPYWEKDD
ASMPLPFDLTDIVSELRGQLLEAKP
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| BDBM50277936 |
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| Name | BDBM50277936 |
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| Synonyms: | (R)-2-(1-chloro-4-hydroxyisoquinoline-3-carboxamido)propanoic acid | CHEMBL485023 |
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| Type | Small organic molecule |
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| Emp. Form. | C13H11ClN2O4 |
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| Mol. Mass. | 294.69 |
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| SMILES | C[C@@H](NC(=O)c1nc(Cl)c2ccccc2c1O)C(O)=O |r| |
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| Structure | 
|
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| n/a |
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