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Target
Arginase-1
Ligand
BDBM50431955
Substrate
n/a
Meas. Tech.
ChEMBL_954166 (CHEMBL2351681)
IC50
5120±n/a nM
Citation
 Golebiowski, A; Paul Beckett, R; Van Zandt, M; Ji, MK; Whitehouse, D; Ryder, TR; Jagdmann, E; Andreoli, M; Mazur, A; Padmanilayam, M; Cousido-Siah, A; Mitschler, A; Ruiz, FX; Podjarny, A; Schroeter, H 2-Substituted-2-amino-6-boronohexanoic acids as arginase inhibitors. Bioorg Med Chem Lett 23:2027-30 (2013) [PubMed]  Article 
Target
Name:
Arginase-1
Synonyms:
ARG1 | ARGI1_HUMAN | Liver-type arginase | Type I arginase
Type:
PROTEIN
Mol. Mass.:
34737.53
Organism:
Homo sapiens (Human)
Description:
ChEMBL_978893
Residue:
322
Sequence:
MSAKSRTIGIIGAPFSKGQPRGGVEEGPTVLRKAGLLEKLKEQECDVKDYGDLPFADIPNDSPFQIVKNPRSVGKASEQLAGKVAEVKKNGRISLVLGGDHSLAIGSISGHARVHPDLGVIWVDAHTDINTPLTTTSGNLHGQPVSFLLKELKGKIPDVPGFSWVTPCISAKDIVYIGLRDVDPGEHYILKTLGIKYFSMTEVDRLGIGKVMEETLSYLLGRKKRPIHLSFDVDGLDPSFTPATGTPVVGGLTYREGLYITEEIYKTGLLSGLDIMEVNPSLGKTPEEVTRTVNTAVAITLACFGLAREGNHKPIDYLNPPK
  
Inhibitor
Name:
BDBM50431955
Synonyms:
CHEMBL2348493
Type:
Small organic molecule
Emp. Form.:
C10H22BNO5
Mol. Mass.:
247.096
SMILES:
COCCCC(N)(CCCCB(O)O)C(O)=O
Structure:
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