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Target
Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial
Ligand
BDBM107747
Substrate
n/a
Meas. Tech.
ChEMBL_950925 (CHEMBL2349998)
IC50
23±n/a nM
Citation
 Dounay, AB; Anderson, M; Bechle, BM; Evrard, E; Gan, X; Kim, JY; McAllister, LA; Pandit, J; Rong, S; Salafia, MA; Tuttle, JB; Zawadzke, LE; Verhoest, PR PF-04859989 as a template for structure-based drug design: identification of new pyrazole series of irreversible KAT II inhibitors with improved lipophilic efficiency. Bioorg Med Chem Lett 23:1961-6 (2013) [PubMed]  Article 
Target
Name:
Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial
Synonyms:
2-aminoadipate aminotransferase | 2-aminoadipate transaminase | AADAT | AADAT_HUMAN | Alpha-aminoadipate aminotransferase | KAT/AadAT | KAT2 | KYAT2 | Kynurenine aminotransferase II | Kynurenine aminotransferase II (KAT II) | Kynurenine--oxoglutarate aminotransferase II | Kynurenine--oxoglutarate transaminase 2 | Kynurenine--oxoglutarate transaminase II
Type:
Enzyme
Mol. Mass.:
47353.09
Organism:
Homo sapiens (Human)
Description:
Q8N5Z0
Residue:
425
Sequence:
MNYARFITAASAARNPSPIRTMTDILSRGPKSMISLAGGLPNPNMFPFKTAVITVENGKTIQFGEEMMKRALQYSPSAGIPELLSWLKQLQIKLHNPPTIHYPPSQGQMDLCVTSGSQQGLCKVFEMIINPGDNVLLDEPAYSGTLQSLHPLGCNIINVASDESGIVPDSLRDILSRWKPEDAKNPQKNTPKFLYTVPNGNNPTGNSLTSERKKEIYELARKYDFLIIEDDPYYFLQFNKFRVPTFLSMDVDGRVIRADSFSKIISSGLRIGFLTGPKPLIERVILHIQVSTLHPSTFNQLMISQLLHEWGEEGFMAHVDRVIDFYSNQKDAILAAADKWLTGLAEWHVPAAGMFLWIKVKGINDVKELIEEKAVKMGVLMLPGNAFYVDSSAPSPYLRASFSSASPEQMDVAFQVLAQLIKESL
  
Inhibitor
Name:
BDBM107747
Synonyms:
CHEMBL2347115 | US8933095, 4
Type:
Small organic molecule
Emp. Form.:
C13H14N4O2
Mol. Mass.:
258.2759
SMILES:
N[C@H]1Cc2c(cnn2Cc2ccccc2)N(O)C1=O |r|
Structure:
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