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Target
Peptidyl-prolyl cis-trans isomerase FKBP5
Ligand
BDBM50432735
Substrate
n/a
Meas. Tech.
ChEMBL_952910 (CHEMBL2351899)
Ki
>100000±n/a nM
Citation
 Wang, Y; Kirschner, A; Fabian, AK; Gopalakrishnan, R; Kress, C; Hoogeland, B; Koch, U; Kozany, C; Bracher, A; Hausch, F Increasing the efficiency of ligands for FK506-binding protein 51 by conformational control. J Med Chem 56:3922-35 (2013) [PubMed]  Article 
Target
Name:
Peptidyl-prolyl cis-trans isomerase FKBP5
Synonyms:
51 kDa FK506-binding protein | 51 kDa FKBP | 54 kDa progesterone receptor-associated immunophilin | AIG6 | Androgen-regulated protein 6 | FF1 antigen | FK506-binding protein 5 | FKBP-5 | FKBP-51 | FKBP5 | FKBP51 | FKBP54 | FKBP5_HUMAN | HSP90-binding immunophilin | PPIase FKBP5 | Rotamase | p54
Type:
PROTEIN
Mol. Mass.:
51207.06
Organism:
Homo sapiens (Human)
Description:
ChEMBL_952910
Residue:
457
Sequence:
MTTDEGAKNNEESPTATVAEQGEDITSKKDRGVLKIVKRVGNGEETPMIGDKVYVHYKGKLSNGKKFDSSHDRNEPFVFSLGKGQVIKAWDIGVATMKKGEICHLLCKPEYAYGSAGSLPKIPSNATLFFEIELLDFKGEDLFEDGGIIRRTKRKGEGYSNPNEGATVEIHLEGRCGGRMFDCRDVAFTVGEGEDHDIPIGIDKALEKMQREEQCILYLGPRYGFGEAGKPKFGIEPNAELIYEVTLKSFEKAKESWEMDTKEKLEQAAIVKEKGTVYFKGGKYMQAVIQYGKIVSWLEMEYGLSEKESKASESFLLAAFLNLAMCYLKLREYTKAVECCDKALGLDSANEKGLYRRGEAQLLMNEFESAKGDFEKVLEVNPQNKAARLQISMCQKKAKEHNERDRRIYANMFKKFAEQDAKEEANKAMGKKTSEGVTNEKGTDSQAMEEEKPEGHV
  
Inhibitor
Name:
BDBM50432735
Synonyms:
CHEMBL2348608
Type:
Small organic molecule
Emp. Form.:
C24H26Cl2N2O6S
Mol. Mass.:
541.444
SMILES:
COc1cc2CCN3C(=O)[C@@H]4CCCC(N4S(=O)(=O)c4cc(Cl)c(O)c(Cl)c4)[C@@]3(C)c2c(OC)c1 |r,TLB:16:15:13.12.11:28.7.8|
Structure:
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